局部放疗联合粒细胞巨噬细胞集落刺激因子治疗后转移性胰腺癌的远隔效应
Abscopal effect of metastatic pancreatic cancer after local radiotherapy and granulocyte-macrophage colony-stimulating factor therapy.
作者信息
Shi Fang, Wang Xin, Teng Feifei, Kong Li, Yu Jinming
机构信息
a Department of Radiation Oncology , Shandong Cancer Hospital and Institute , Jinan , Shandong Province , China.
b School of Medicine and Life Sciences , University of Jinan-Shandong Academy of Medical Sciences , Jinan , Shandong Province , China.
出版信息
Cancer Biol Ther. 2017 Mar 4;18(3):137-141. doi: 10.1080/15384047.2016.1276133.
Abstract
The role of immunotherapy in combination with traditional treatment regime in improving the survival of cancer patients has attracted more and more attention. Especially the abscopal effect that describes the phenomenon of localized radiotherapy leading to regression of distant unirradiated tumors and the role of enhanced radiotherapy-induced immunogenic cell death and activation of immune system have become a focus of the studies. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known a powerful stimulator of the generation, migration and activation of antigen presenting cells such as dendritic cells (DC) and macrophages. Here we report a case of a 67-year-old refractory metastatic pancreatic cancer patient who obtained evident abscopal effect and survival benefit from concurrent localized radiotherapy and GM-CSF.
摘要
免疫疗法联合传统治疗方案在提高癌症患者生存率方面的作用已引起越来越多的关注。特别是“远隔效应”，即局部放疗导致远处未受照射肿瘤消退的现象，以及放疗诱导的免疫原性细胞死亡增强和免疫系统激活的作用，已成为研究的焦点。粒细胞巨噬细胞集落刺激因子（GM-CSF）是一种强大的刺激剂，可刺激抗原呈递细胞如树突状细胞（DC）和巨噬细胞的生成、迁移和激活。在此，我们报告一例67岁的难治性转移性胰腺癌患者，该患者通过同步局部放疗和GM-CSF获得了明显的远隔效应和生存获益。
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