Tomaciello Miriam, Conte Miriam, Montinaro Francesca Romana, Sabatini Arianna, Cunicella Giorgia, Di Giammarco Federico, Tini Paolo, Gravina Giovanni Luca, Cortesi Enrico, Minniti Giuseppe, De Vincentis Giuseppe, Frantellizzi Viviana, Marampon Francesco
Department of Radiological Sciences, Oncology and Anatomical Pathology, Division of Radiotherapy, Sapienza University of Rome, 00161 Rome, Italy.
Department of Radiological Sciences, Oncology and Anatomical Pathology, Division of Nuclear Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Biomedicines. 2023 Apr 12;11(4):1157. doi: 10.3390/biomedicines11041157.
Abscopal effect (AE) describes the ability of radiotherapy (RT) to induce immune-mediated responses in nonirradiated distant metastasis. Bone represents the third most frequent site of metastasis and an immunologically favorable environment for the proliferation of cancer cells. We revised the literature, searching documented cases of AE involving bone metastases (BMs) and evaluated the incidence of AE involving BMs in patients requiring palliative RT on BMs or non-BMs treated at our department.
Articles published in the PubMed/MEDLINE database were selected using the following search criteria: ((abscopal effect)) AND ((metastases)). Patients with BMs, who underwent performed bone scintigraphy before and at least 2-3 months after RT, were selected and screened between January 2015 and July 2022. AE was defined as an objective response according to the scan bone index for at least one nonirradiated metastasis at a distance > 10 cm from the irradiated lesion. The primary endpoint was the rate of AE on BMs.
Ten cases experiencing AE of BMs were identified from the literature and eight among our patients.
The analysis performed here suggests the use of hypofractionated radiotherapy as the only triggering factor for AE of BMs through the activation of the immune response.
远隔效应（AE）描述了放射治疗（RT）在未受照射的远处转移灶中诱导免疫介导反应的能力。骨是第三常见的转移部位，也是癌细胞增殖的免疫有利环境。我们查阅了文献，检索记录在案的涉及骨转移（BM）的远隔效应病例，并评估了在我们科室接受BM或非BM姑息性放疗的患者中涉及BM的远隔效应的发生率。
使用以下检索标准选择发表在PubMed/MEDLINE数据库中的文章：（（远隔效应））和（（转移））。选择2015年1月至2022年7月期间接受RT前及RT后至少2-3个月进行骨闪烁显像的BM患者并进行筛查。远隔效应根据扫描骨指数定义为距照射病灶>10 cm处至少一个未受照射转移灶的客观反应。主要终点是BM的远隔效应发生率。
从文献中确定了10例发生BM远隔效应的病例，我们的患者中有8例。
此处进行的分析表明，通过激活免疫反应，使用低分割放疗作为BM远隔效应的唯一触发因素。
