Pike Mindy M, Larson Nicholas B, Wassel Christina L, Cohoon Kevin P, Tsai Michael Y, Pankow James S, Hanson Naomi Q, Decker Paul A, Berardi Cecilia, Alexander Kristine S, Cushman Mary, Zakai Neil A, Bielinski Suzette J
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Thromb Res. 2017 May;153:1-6. doi: 10.1016/j.thromres.2017.02.018. Epub 2017 Feb 24.
Peripheral artery disease (PAD) affects 8.5 million Americans and thus improving our understanding of PAD is critical to developing strategies to reduce disease burden. The objective of the study was to determine the association of ABO blood type with ankle brachial index (ABI) as well as prevalent and incident PAD in a multi-ethnic cohort.
The Multi-Ethnic Study of Atherosclerosis includes non-Hispanic White, African, Hispanic, and Chinese Americans aged 45-84. ABO blood type was estimated using ABO genotypes in 6027 participants who had ABI assessed at the baseline exam. Associations with ABO blood type were evaluated categorically and under an additive genetic model by number of major ABO alleles. After excluding those with ABI>1.4, prevalent PAD was defined as ABI≤0.9 at baseline and incident PAD as ABI≤0.9 for 5137 participants eligible for analysis.
There were 222 prevalent cases and 239 incident cases of PAD. In African Americans, each additional copy of the A allele was associated with a 0.02 lower baseline ABI (p=0.006). Each copy of the A allele also corresponded to 1.57-fold greater odds of prevalent PAD (95% CI, 1.17-2.35; p=0.004), but was not associated with incident PAD. No associations were found in other racial/ethnic groups for ABI, prevalent PAD, or incident PAD across all races/ethnicities.
Blood type A and the A allele count were significantly associated with baseline ABI and prevalent PAD in African Americans. Further research is needed to confirm and study the mechanisms of this association in African Americans.
外周动脉疾病（PAD）影响着850万美国人，因此增进我们对PAD的了解对于制定减轻疾病负担的策略至关重要。本研究的目的是在一个多民族队列中确定ABO血型与踝臂指数（ABI）以及现患和新发PAD之间的关联。
动脉粥样硬化多民族研究纳入了年龄在45 - 84岁的非西班牙裔白人、非洲裔、西班牙裔和华裔美国人。在6027名基线检查时进行了ABI评估的参与者中，利用ABO基因型估计ABO血型。通过ABO主要等位基因数量，对ABO血型的关联进行分类评估，并在加性遗传模型下进行评估。在排除ABI>1.4的人群后，对于5137名符合分析条件的参与者，现患PAD定义为基线时ABI≤0.9，新发PAD定义为ABI≤0.9。
有222例现患PAD病例和239例新发PAD病例。在非洲裔美国人中，A等位基因每增加一份，基线ABI降低0.02（p = 0.006）。A等位基因的每一份还对应着现患PAD的几率高出1.57倍（95%CI，1.17 - 2.35；p = 0.004），但与新发PAD无关。在其他种族/民族群体中，未发现ABI、现患PAD或新发PAD与所有种族/民族群体之间存在关联。
在非洲裔美国人中，A型血和A等位基因计数与基线ABI和现患PAD显著相关。需要进一步研究以证实并研究非洲裔美国人中这种关联的机制。
