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狼疮抗凝物致年轻女性颈动脉漂浮血栓性卒中:一例报告并文献复习

Carotid free-floating thrombus causing stroke in a young woman with lupus anticoagulant: A case report and review of the literature.

作者信息

Afsharfard Abolfazl, Gholizadeh Barmak, Abdolalian Younes, Hosseini Seyed Masoud

机构信息

General and Vascular Surgery, Shohada Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

General Surgery, Shahid Modarres Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Int J Surg Case Rep. 2017;33:35-37. doi: 10.1016/j.ijscr.2017.01.067. Epub 2017 Feb 20.

Abstract

INTRODUCTION

In young adults Stroke is a challenging condition and various tests are needed to diagnose and manage its underlying problems. Free floating thrombosis of internal carotid artery (FFT-ICA) is one of the rare problems among carotid artery diseases which can lead to stroke in adults. Owing to limited cases of FFT-ICA there is not a worldwide accepted consensus on management of FFT-ICA, but some recurrences after medical management have been reported in the literature.

PRESENTATION OF CASE

A-25-year old woman was referred to hospital with sudden onset aphasia and right sided hemiparesis. Carotid duplex ultrasonography showed an iso-echogenic thrombus ranged about 5×10mm partially attached to arterial wall of the right internal carotid artery. It was floating in accordance with the heartbeat. Anticoagulation therapy was initiated and subsequently she underwent an urgent operation. To explore the etiology of her problem, various lab tests were carried out; the results showed markedly elevated levels of lupus anticoagulant. She was discharged from hospital after an uneventful recovery showing gradual improvement of symptoms in follow-up visits.

DISCUSSION

FFT-ICA is one of the scarce disorders of carotid artery. Less than 150 cases have been reported in the literature indicating its common occurrence in old men. Hence the etiology of this case (FFT in a young patient with high levels of lupus anticoagulant antibody) may be the first of its type.

CONCLUSION

In this case we chose surgical treatment resulting in complete resolution of symptoms and non-recurrence within 6 month follow-up.

摘要

引言

在年轻人中,中风是一种具有挑战性的病症,需要进行各种检查来诊断和处理其潜在问题。颈内动脉游离血栓形成(FFT-ICA)是颈动脉疾病中罕见的问题之一,可导致成人中风。由于FFT-ICA病例有限,目前全球对于FFT-ICA的治疗尚无公认的共识,但文献中已报道了一些药物治疗后的复发情况。

病例介绍

一名25岁女性因突然出现失语和右侧偏瘫被转诊至医院。颈动脉双功超声检查显示,一个大小约为5×10mm的等回声血栓部分附着于右侧颈内动脉的动脉壁上。它随心跳浮动。开始进行抗凝治疗,随后她接受了紧急手术。为探究其问题的病因,进行了各种实验室检查;结果显示狼疮抗凝物水平显著升高。她在顺利康复后出院,随访中症状逐渐改善。

讨论

FFT-ICA是颈动脉罕见疾病之一。文献报道的病例少于150例,表明其在老年男性中较为常见。因此,该病例(一名狼疮抗凝抗体水平高的年轻患者出现FFT)的病因可能属首例。

结论

在本病例中,我们选择了手术治疗,症状完全缓解,随访6个月内未复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bec6/5338895/4ecaec26446d/gr1.jpg

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