Zhang C, Peng Y, Li S, Zhou P, Munoz A, Tang D, Zhang Y
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:121-124. doi: 10.1109/EMBC.2016.7590655.
The three dimensional (3D) innervation zone (IZ) imaging approach (3DIZI) has been developed in our group to localize the IZ of a particular motor unit (MU) from its motor unit action potentials decomposed from high-density surface electromyography (EMG) recordings. In this study, the developed 3DIZI approach was combined with electrical stimulation to investigate global distributions of IZs in muscles from electrically elicited M-wave recordings. Electrical stimulations were applied to the musculocutaneous nerve to activate supramaximal muscle response of the biceps brachii in one healthy subject, and high-density (128 channels) surface EMG signals of the biceps brachii muscles were recorded. The 3DIZI approach was then employed to image the IZ distribution of IZs in the 3D space of the biceps brachii. The performance of the M-wave based 3DIZI approach was evaluated with different stimulation intensities. Results show that the reconstructed IZs under supramaximal stimulation are spatially distributed in the center region of muscle belly which is consistent with previous studies. With sub-maximal stimulation intensity, the imaged IZ centers became more proximally and deeply located. The proposed M-wave based 3DIZI approach demonstrated its capability of imaging global distribution of IZs in muscles, which provide valuable information for clinical applications such as guiding botulinum toxin injection in treating muscle spasticity.
我们团队开发了三维（3D）神经支配区（IZ）成像方法（3DIZI），用于从高密度表面肌电图（EMG）记录中分解出的特定运动单元（MU）的运动单元动作电位来定位其IZ。在本研究中，将已开发的3DIZI方法与电刺激相结合，通过电诱发M波记录来研究肌肉中IZ的整体分布。对一名健康受试者的肌皮神经施加电刺激，以激活肱二头肌的最大肌肉反应，并记录肱二头肌的高密度（128通道）表面EMG信号。然后采用3DIZI方法对肱二头肌三维空间中的IZ分布进行成像。基于M波的3DIZI方法的性能在不同刺激强度下进行了评估。结果表明，最大刺激下重建的IZ在肌肉腹部中心区域呈空间分布，这与先前的研究一致。在次最大刺激强度下，成像的IZ中心位置更靠近近端且更深。所提出的基于M波的3DIZI方法展示了其对肌肉中IZ整体分布进行成像的能力，这为临床应用提供了有价值的信息，如指导肉毒杆菌毒素注射治疗肌肉痉挛。
