[肌酸激酶BB和神经元特异性烯醇化酶作为肺癌的生物标志物]

[Creatine kinase BB and neuron specific r-enolase as biomarkers for lung cancer].

作者信息

Usui A, Fujita K, Imaizumi M, Abe T, Inoue K, Matsumoto S, Kato K

机构信息

Dept. of Thoracic Surgery, Nagoya, Univ., School of Med.

出版信息

Gan No Rinsho. 1987 Nov;33(14):1763-70.

PMID:2826840

Abstract

The serum concentrations of both CK-BB and NSE in patients with various lung carcinoma have been determined by the enzyme immunoassay. Serum CK-BB levels were found to be significantly increased (less than 1.0 ng/ml) in patients with a small cell carcinoma (51 cases, 74.5%), adenocarcinoma (77 cases, 36.5%), and a squamous cell carcinoma (68 cases, 39.7%). The serum NSE levels also were increased (less than 6.0 ng/ml) in cases of small cell carcinoma (72.5%), adenocarcinoma (27.3%), and squamous cell carcinoma (26.5%). Since the serum concentrations of bos CK-BB and NSE changed in parallel with the clinical course, they may be useful biomarkers for monitoring the clinical course of patients with lung cancer, especially in cases of small cell carcinoma.

摘要

采用酶免疫分析法测定了各类肺癌患者血清中肌酸激酶脑型同工酶（CK-BB）和神经元特异性烯醇化酶（NSE）的浓度。发现小细胞癌患者（51例，74.5%）、腺癌患者（77例，36.5%）和鳞状细胞癌患者（68例，39.7%）的血清CK-BB水平显著升高（低于1.0 ng/ml）。小细胞癌患者（72.5%）、腺癌患者（27.3%）和鳞状细胞癌患者（26.5%）的血清NSE水平也升高（低于6.0 ng/ml）。由于血清中CK-BB和NSE的浓度随临床病程平行变化，它们可能是监测肺癌患者临床病程的有用生物标志物，尤其是在小细胞癌病例中。