Nakajima T, Mizushima N, Kanai K
Second Department of Internal Medicine, Hamamatsu University School of Medicine, Japan.
Jpn J Clin Oncol. 1987 Dec;17(4):327-32.
Natural killer (NK) activities of peripheral blood lymphocytes (PBL) in 50 patients with non-alcoholic liver cirrhosis (LC) were prospectively studied in order to clarify the relation between the development of hepatocellular carcinoma (HCC) and impaired NK activities. Patients were divided into two groups according to their NK activities at the beginning of the study, namely, Group A with normal NK activity (n = 21) and Group B with decreased NK activity (n = 29). NK activities were serially determined in each patient for up to 40 months. During the observation period, the occurrence of HCC was identified in 12 patients (four to 36 months). Of the patients who developed HCCs, two belonged to Group A (9.5%) and 10 belonged to Group B (34.5%). These results suggest decreased NK activity in LC patients to be one of the critical factors increasing their risk of developing HCC, and serial determinations of NK activities to be important in predicting the occurrence of HCCs in following the clinical course of LC patients.
为了阐明肝细胞癌（HCC）的发生与自然杀伤（NK）活性受损之间的关系，对50例非酒精性肝硬化（LC）患者外周血淋巴细胞（PBL）的NK活性进行了前瞻性研究。根据研究开始时的NK活性，将患者分为两组，即NK活性正常的A组（n = 21）和NK活性降低的B组（n = 29）。对每位患者连续测定NK活性长达40个月。在观察期内，12例患者（4至36个月）确诊发生HCC。在发生HCC的患者中，2例属于A组（9.5%），10例属于B组（34.5%）。这些结果表明，LC患者NK活性降低是增加其发生HCC风险的关键因素之一，并且连续测定NK活性对于预测LC患者临床病程中HCC的发生具有重要意义。
