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将非人类灵长类动物的体内颅内记录与优化经颅电刺激的预测结果进行比较。

On comparing in vivo intracranial recordings in non-human primates to predictions of optimized transcranial electrical stimulation.

作者信息

Datta Abhishek, Krause Matthew R, Pilly Praveen K, Choe Jaehoon, Zanos Theodoras P, Thomas Chris, Pack Christopher C

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:1774-1777. doi: 10.1109/EMBC.2016.7591061.

DOI:10.1109/EMBC.2016.7591061
PMID:28268671
Abstract

Transcranial electrical stimulation (tES) can be optimized to achieve maximal current flow at desired brain regions. The aim of this study was to characterize electric field magnitudes generated by tES optimization and to compare them to experimentally induced values as determined by data from intracranial electrodes. Local field potentials were recorded from two monkeys with implanted multi-site intracranial Utah arrays during transcranial direct current stimulation (tDCS), and the neural effect predictions obtained from optimized electrode placement were assessed. Comparative data between the two sites of intracranial recordings during tDCS partially validated the predictions of our tES optimization algorithms.

摘要

经颅电刺激(tES)可以进行优化,以在期望的脑区实现最大电流流动。本研究的目的是表征由tES优化产生的电场强度,并将其与通过颅内电极数据确定的实验诱导值进行比较。在经颅直流电刺激(tDCS)期间,从两只植入了多部位颅内犹他阵列的猴子记录局部场电位,并评估从优化电极放置获得的神经效应预测。tDCS期间颅内记录两个部位之间的比较数据部分验证了我们的tES优化算法的预测。

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