铌酸锂上微接触印刷分子的新型折射率生物传感

Novel refractive index biosensing of microcontact printed molecules on lithium niobate.

作者信息

Bhalla Nikhil, Sathish Shivani, Shen Amy Q

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:2095-2098. doi: 10.1109/EMBC.2016.7591141.

DOI:10.1109/EMBC.2016.7591141

Abstract

This work demonstrates, for the first time, the use of lithium niobate as a biosensor that detects local refractive index changes triggered by the presence of biomolecules on its surface. The sensitivity of the sensor was found to be 242±16 nm/RIU. As a case study, we immobilized proteins (IgG antibodies) using micro-contact printing to demonstrate sensing capabilities of the device. The validated proof of concept lays a foundation for developing lithium niobate based novel optical biosensors.

摘要

这项工作首次展示了将铌酸锂用作生物传感器，该传感器可检测由其表面生物分子的存在引发的局部折射率变化。发现该传感器的灵敏度为242±16 nm/RIU。作为一个案例研究，我们使用微接触印刷固定蛋白质（IgG抗体），以证明该设备的传感能力。经过验证的概念验证为开发基于铌酸锂的新型光学生物传感器奠定了基础。