正常及猿猴病毒40转化的NIH 3T3细胞中p53的磷酸化作用
Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells.
作者信息
Meek D W, Eckhart W
机构信息
Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, San Diego, California 92138.
出版信息
Mol Cell Biol. 1988 Jan;8(1):461-5. doi: 10.1128/mcb.8.1.461-465.1988.
We observed six major tryptic phosphopeptides in p53 from simian virus 40-transformed and normal NIH 3T3 cells. Analyses of the phosphopeptides indicated that serines 37, 310 and/or 312, 389 and one or more of serines 7, 9, 12, 18, and 23 were phosphorylated. Phosphorylation of serines 310 and/or 312 was twofold higher in the simian virus 40-transformed cells as compared with that in normal NIH 3T3 cells.
我们在来自猿猴病毒40转化的和正常的NIH 3T3细胞的p53中观察到六种主要的胰蛋白酶磷酸肽。对这些磷酸肽的分析表明，丝氨酸37、310和/或312、389以及丝氨酸7、9、12、18和23中的一个或多个被磷酸化。与正常NIH 3T3细胞相比，猿猴病毒40转化细胞中丝氨酸310和/或312的磷酸化水平高出两倍。
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