通过对转基因小鼠中融合基因的分析揭示的小鼠乳腺肿瘤病毒长末端重复序列中的多个调控结构域。
Multiple regulatory domains in the mouse mammary tumor virus long terminal repeat revealed by analysis of fusion genes in transgenic mice.
作者信息
Stewart T A, Hollingshead P G, Pitts S L
机构信息
Department of Developmental Biology, Genentech, Inc., South San Francisco, California 94080.
出版信息
Mol Cell Biol. 1988 Jan;8(1):473-9. doi: 10.1128/mcb.8.1.473-479.1988.
Abstract
Transcription initiated within the mouse mammary tumor virus (MTV) long terminal repeat (LTR) is regulated by glucocorticoids, androgens, and estrogen. However, expression of the virus in vivo and transcription of MTV LTR fusion genes in transgenic mice are not readily interpretable solely in terms of the influence of these hormones. To investigate whether there is a regulatory role for sequences within the LTR but outside the region known to be responsible for glucocorticoid induction, we have produced transgenic mice carrying genes in which various regions of the LTR have been linked to the human growth hormone gene. Analysis of expression of the fusion genes in these transgenic mice has demonstrated that the 5' end of the LTR can profoundly influence transcription initiated within the MTV LTR.
摘要
在小鼠乳腺肿瘤病毒（MTV）长末端重复序列（LTR）内起始的转录受糖皮质激素、雄激素和雌激素调控。然而，该病毒在体内的表达以及转基因小鼠中MTV LTR融合基因的转录，仅根据这些激素的影响难以轻易解释。为了研究LTR内已知负责糖皮质激素诱导的区域之外的序列是否具有调控作用，我们培育了携带基因的转基因小鼠，这些基因中LTR的各个区域已与人生长激素基因相连。对这些转基因小鼠中融合基因表达的分析表明，LTR的5'端可深刻影响在MTV LTR内起始的转录。
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