Frost J J
Division of Nuclear Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
NIDA Res Monogr. 1986;74:15-24.
In summary, it is now possible to image the distribution of several neurotransmitter receptors by PET. When quantitative estimates of receptor number and affinity can be made, it will be important to study (1) changes in receptor number or affinity as a function of disease, (2) changes in receptor occupancy by endogenous neurotransmitters, and (3) changes in receptor occupancy and correlation with behavior during drug treatment.
总之，现在通过正电子发射断层扫描（PET）对多种神经递质受体的分布进行成像已成为可能。当能够对受体数量和亲和力进行定量估计时，研究以下内容将非常重要：（1）受体数量或亲和力随疾病的变化；（2）内源性神经递质对受体占有率的变化；（3）药物治疗期间受体占有率的变化及其与行为的相关性。
