Frost J J
Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Invest Radiol. 1992 Dec;27 Suppl 2:S54-8. doi: 10.1097/00004424-199212002-00010.
Positron emission tomography (PET) has been used primarily to measure regional brain metabolism and blood flow. Single-photon emission computed tomography (SPECT) also can be used to measure brain perfusion. Receptor imaging by PET and SPECT, however, offers distinctive advantages over the more established flow/metabolism imaging methods, including improved chemical specificity and improved sensitivity in detecting changes in disease. Radioligands are available for PET and SPECT imaging of many neuroreceptors, including the opiate receptor, the dopamine receptor, and the muscarinic cholinergic receptor. A new focus of interest is the imaging and quantification of presynaptic neurotransmitter reuptake sites.
正电子发射断层扫描（PET）主要用于测量局部脑代谢和血流量。单光子发射计算机断层扫描（SPECT）也可用于测量脑灌注。然而，与更成熟的血流/代谢成像方法相比，PET和SPECT的受体成像具有独特的优势，包括提高化学特异性和检测疾病变化的灵敏度。有多种放射性配体可用于许多神经受体的PET和SPECT成像，包括阿片受体、多巴胺受体和毒蕈碱胆碱能受体。一个新的研究热点是突触前神经递质再摄取位点的成像和定量分析。
