Shibata S, Okada M, Natori Y, Shindo N, Oshima M
Clinical Research Institute, National Medical Center, Tokyo, Japan.
Nephron. 1987;47(2):101-8. doi: 10.1159/000184469.
Glomerular lesions were successfully induced in rats by a single footpad injection of synthetic analogues of nephritogenoside [alpha-Glc-(1----6)-alpha-Glc-(1-NHCO-Asn, and -Gln)]. Characteristic morphological changes of these glomerular lesions are (1) focal glomerulonephritis (FGN) and (2) the appearance of myeloid bodies in the epithelial cells of the podocytes. FGN produced by a single injection of the synthetic analogues of nephritogenoside may provide an experimental animal model of this potentially diffuse disease, since morphological changes in the early stage of sclerosing glomerulonephritis (end-stage kidney) induced by a single footpad injection of natural nephritogenoside are often identical to those of FGN.
通过在大鼠足垫单次注射肾炎原苷的合成类似物[α-Glc-(1→6)-α-Glc-(1-NHCO-Asn和-Gln)]成功诱导出肾小球病变。这些肾小球病变的特征性形态学变化为：(1)局灶性肾小球肾炎(FGN)；(2)足细胞上皮细胞中出现髓样小体。单次注射肾炎原苷的合成类似物所产生的FGN可能为此种潜在的弥漫性疾病提供一种实验动物模型，因为单次足垫注射天然肾炎原苷所诱导的硬化性肾小球肾炎（终末期肾病）早期的形态学变化常与FGN的变化相同。
