UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK.
Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK; and The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Nat Rev Mol Cell Biol. 2017 May;18(5):331-337. doi: 10.1038/nrm.2017.12. Epub 2017 Mar 8.
Transcription and chromatin function are regulated by proteins that bind to DNA, nucleosomes or RNA polymerase II, with specific non-coding RNAs (ncRNAs) functioning to modulate their recruitment or activity. Unlike ncRNAs, nascent pre-mRNA was considered to be primarily a passive player in these processes. In this Opinion article, we describe recently identified interactions between nascent pre-mRNAs and regulatory proteins, highlight commonalities between the functions of nascent pre-mRNA and nascent ncRNA, and propose that both types of RNA have an active role in transcription and chromatin regulation.
转录和染色质功能受与 DNA、核小体或 RNA 聚合酶 II 结合的蛋白质调控，特定的非编码 RNA（ncRNA）可以调节它们的募集或活性。与 ncRNA 不同，新生的前体 mRNA 被认为主要是这些过程中的被动参与者。在这篇观点文章中，我们描述了新生前体 mRNA 与调节蛋白之间新发现的相互作用，强调了新生前体 mRNA 和新生 ncRNA 功能之间的共性，并提出这两种类型的 RNA 在转录和染色质调控中都具有积极作用。
