Jain C, Caulley L, Macdonald K I, Purgina B, Lai C K, Esche B, Johnson-Obaseki S
Faculty of Medicine, University of Ottawa.
Department of Otolaryngology-Head and Neck Surgery, University of Ottawa;; The Ottawa Hospital.
Curr Oncol. 2017 Feb;24(1):e55-e60. doi: 10.3747/co.24.3299. Epub 2017 Feb 27.
Non-intestinal-type adenocarcinoma is a malignancy traditionally found in the sinonasal cavity. To our knowledge, this case is the first reported of this rare condition originating in the nasopharynx.
A 67-year-old woman with nasopharyngeal non-intestinal-type adenocarcinoma, with an accompanying parapharyngeal mass received primary radiation treatment for both lesions. Her tumour subsequently persisted, with a concomitant conversion in pathology from a low- to a high-grade malignancy.
Non-intestinal-type and intestinal-type adenocarcinomas of the nasopharynx are extremely rare tumours and do not appear in the World Health Organization classification system. We review the pathophysiologic features of these malignancies and propose modifications to the current classification system.
Non-intestinal-type adenocarcinoma should be included in the differential diagnosis of nasopharyngeal masses. In our experience, this tumour in this location showed a partial response to primary radiation but later converted from a low- to a high-grade adenocarcinoma.
非肠型腺癌是一种传统上见于鼻窦腔的恶性肿瘤。据我们所知，该病例是首例报道的起源于鼻咽部的这种罕见疾病。
一名67岁患有鼻咽部非肠型腺癌并伴有咽旁肿块的女性，对这两个病灶接受了初次放射治疗。她的肿瘤随后持续存在，同时病理从低级别恶性转变为高级别恶性。
鼻咽部非肠型和肠型腺癌是极其罕见的肿瘤，未出现在世界卫生组织分类系统中。我们回顾了这些恶性肿瘤的病理生理特征，并对当前分类系统提出修改建议。
非肠型腺癌应纳入鼻咽部肿块的鉴别诊断。根据我们的经验，该部位的这种肿瘤对初次放射治疗有部分反应，但后来从低级别腺癌转变为高级别腺癌。
