Nagao Mizuho, Borres Magnus P, Sugimoto Mayumi, Petersson Carl Johan, Nakayama Satoshi, Kuwabara Yu, Masuda Sawako, Dykiel Patrik, Fujisawa Takao
Allergy Center and Department of Clinical Research, Mie National Hospital, IDD, Tsu, Mie Japan.
Thermo Fisher Scientific, Uppsala, Sweden.
Clin Mol Allergy. 2017 Mar 3;15:4. doi: 10.1186/s12948-017-0061-8. eCollection 2017.
Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physician-diagnosed atopic dermatitis and/or showing food allergy symptoms and to examine the relation to asthma development.
Three-hundred and four children (median age 13.4 months at entry) with food allergy symptoms and/or atopic dermatitis without asthma at inclusion were analysed for IgE antibodies against food-, indoor- and outdoor-allergens and pet allergen components and correlated to the individuals' outcome on asthma inception.
At 2 years of follow-up, physician-diagnosed asthma was 19.7% (n = 49) and asthma diagnosed any time was 24% (n = 67). History of persistent cough and asthma of father, combination of milk- and wheat-allergy symptoms and dual sensitization to house dust mite and Japanese cedar were independent risk factors for asthma. Sensitization to dog was the most prevalent inhalant allergen at entry. Asthma children had a higher proportion of sensitization to dog, cat and horse allergens at entry compared with non-asthma children. Being sensitized to both food, house dust mite and pet allergens was strongly associated with asthma (p = 0.0006). Component resolved diagnosis for dog and cat allergens showed that IgE antibodies to Can f 1 and Fel d 1 was common even at very young age.
Early sensitization to inhalant allergens increases the risk of developing asthma as well as having milk and wheat allergy symptoms. Sensitization to dog, was common at an early age despite dog ownership. Sensitization to secretoglobin and lipocalins and less to serum albumins explained the pet sensitization.
据报道，幼年时期的多种致敏情况是哮喘发病的一个风险因素。本研究评估了一组经医生诊断患有特应性皮炎和/或有食物过敏症状的儿童中，针对空气过敏原的IgE的出现和演变情况，并研究其与哮喘发病的关系。
对304名（入组时中位年龄13.4个月）有食物过敏症状和/或特应性皮炎且入组时无哮喘的儿童进行分析，检测其针对食物、室内和室外过敏原以及宠物过敏原成分的IgE抗体，并将其与个体哮喘发病的结果相关联。
在2年的随访中，医生诊断的哮喘发生率为19.7%（n = 49），任何时间诊断的哮喘发生率为24%（n = 67）。持续性咳嗽病史和父亲的哮喘病史、牛奶和小麦过敏症状的组合以及对屋尘螨和日本雪松的双重致敏是哮喘的独立风险因素。对狗的致敏是入组时最常见的吸入性过敏原。与非哮喘儿童相比，哮喘儿童在入组时对狗、猫和马过敏原的致敏比例更高。对食物、屋尘螨和宠物过敏原均致敏与哮喘密切相关（p = 0.0006）。对狗和猫过敏原的成分解析诊断表明，即使在非常年幼的年龄，针对犬小孢子菌1和猫毛球蛋白1的IgE抗体也很常见。
早期对吸入性过敏原的致敏会增加患哮喘以及出现牛奶和小麦过敏症状的风险。尽管养宠物，但对狗的致敏在幼年时期很常见。对分泌球蛋白和脂质运载蛋白的致敏以及对血清白蛋白的致敏较少解释了对宠物的致敏情况。
