Özuygur Ermis Saliha Selin, Norouzi Aram, Borres Magnus P, Basna Rani, Ekerljung Linda, Malmhäll Carina, Goksör Emma, Wennergren Göran, Rådinger Madeleine, Lötvall Jan, Kankaanranta Hannu, Nwaru Bright I
Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Norvia Kliniken, Solna, Sweden.
Clin Transl Allergy. 2023 Aug;13(8):e12294. doi: 10.1002/clt2.12294.
The use of molecular allergology has increasingly become common in the diagnosis and management of allergic diseases. However, there is still a lack of data on cat molecular allergens in adults. Therefore, we aimed to uncover the sensitization patterns to cat molecular allergens.
Participants were recruited from the West Asthma Sweden Study, a population-based study enriched with asthma subjects aged 16-75 years. Of 1872, 361 individuals were positive for cat dander immunoglobulin E and were further analysed for cat molecular allergens (Fel d 1/2/4/7). Sensitization patterns were classified as monosensitization, polysensitization, and concomitant sensitization, and were related to demographic and clinical measurements.
Among cat-sensitized subjects, 84.2% were sensitized to secretoglobin, while 42.4% were sensitized to lipocalins. Nearly half of the subjects were monosensitized to Fel d 1. Polysensitization was observed in 20.2%, and concomitant sensitization to protein families was seen in 7.2%. Asthma prevalence, cat exposure, and rural living were associated with poly- and concomitant sensitization to protein families. Concomitant sensitization to single allergens was more common in those with asthma than in those without, while concomitant sensitization to both Fel d 1 and Fel d 4 was the most common pattern in individuals with asthma. Sensitization patterns also differed according to cat ownership and the degree of urbanization.
Sensitization to molecular allergens was observed in 90.9% of cat-sensitized subjects and showed variations across participants' background characteristics and the presence of asthma. Identification of sensitization patterns to cat allergens might provide better characterization of cat-allergic subjects.
分子变应性学在过敏性疾病的诊断和管理中的应用日益普遍。然而，关于成人猫分子变应原的数据仍然缺乏。因此，我们旨在揭示对猫分子变应原的致敏模式。
参与者来自瑞典西部哮喘研究，这是一项以人群为基础的研究，纳入了16 - 75岁的哮喘患者。在1872名参与者中，361人猫皮屑免疫球蛋白E呈阳性，并进一步分析其猫分子变应原（猫过敏原1/2/4/7）。致敏模式分为单致敏、多致敏和伴随致敏，并与人口统计学和临床测量指标相关。
在对猫致敏的受试者中，84.2%对分泌球蛋白致敏，而42.4%对脂质运载蛋白致敏。近一半的受试者对猫过敏原1单致敏。观察到20.2%的受试者有多致敏现象，7.2%的受试者对蛋白质家族有伴随致敏现象。哮喘患病率、猫暴露情况和农村居住与对蛋白质家族的多致敏和伴随致敏有关。哮喘患者中对单一变应原的伴随致敏比非哮喘患者更常见，而对猫过敏原1和猫过敏原4的伴随致敏是哮喘患者中最常见的模式。致敏模式也因是否养猫和城市化程度而异。
在90.9%的猫致敏受试者中观察到对分子变应原的致敏现象，并且在参与者的背景特征和哮喘存在情况方面存在差异。识别对猫变应原的致敏模式可能有助于更好地描述猫过敏受试者的特征。
