Rohani Farzaneh, Golgiri Fatemeh, Alaei Mohammad Reza, Karimi Mojgan, Nikraftar Parham, Bozorgmehr Ramin
Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Science, Tehran, Iran ; Department of Endocrinology and Metabolism, Ali-Asghar Children's Hospital, Iran University of Medical Sciences, Tehran, Iran.
Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
Gastroenterology Res. 2017 Feb;10(1):28-32. doi: 10.14740/gr778w. Epub 2017 Feb 21.
Liver enzyme abnormalities have been reported in Turner's syndrome (TS). There are some studies about possible causes of abnormal levels of liver enzymes. One of the main suggestions is obesity. The study aimed to determine the relationship between obesity and liver enzymes levels in patients with TS.
Forty-one karyotype-proven TS patients referred to Endocrinology and Metabolism Research Center were included in this cross-sectional study. Height and weight of patients were measured and their body mass index (BMI) was calculated. The patients were divided into two groups as the control group including 27 cases (65.8%) with normal BMI (defined as < 85th percentile for age and gender), and the overweight group including 14 cases (34.2%) (defined as BMI > 85th percentile for age and gender). Serum levels of aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (AlkPh) were measured.
There were no statistically significant differences regarding AST (27 ± 2.7 vs. 29.6 ± 5.85 U/L; P = 0.3), ALT (20.1 ± 2.45 vs. 22.2 ± 5.85 U/L; P = 0.5), and AlkPh (583.4 ± 2.45 vs. 472.8 ± 161.5 U/L; P = 0.28) between overweight TS patients and those with normal BMI.
There was no significant difference in liver enzyme levels between TS patients with normal BMI and those who were overweight.
已有报道称特纳综合征（TS）患者存在肝酶异常。关于肝酶水平异常的可能原因有一些研究。其中一个主要观点是肥胖。本研究旨在确定TS患者中肥胖与肝酶水平之间的关系。
本横断面研究纳入了41名经核型证实的TS患者，这些患者均转诊至内分泌与代谢研究中心。测量患者的身高和体重，并计算其体重指数（BMI）。患者被分为两组，对照组包括27例（65.8%）BMI正常（定义为年龄和性别对应的BMI低于第85百分位数）的患者，超重组包括14例（34.2%）（定义为年龄和性别对应的BMI高于第85百分位数）的患者。检测血清天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）和碱性磷酸酶（AlkPh）水平。
超重的TS患者与BMI正常的TS患者在AST（27±2.7对29.6±5.85 U/L；P = 0.3）、ALT（20.1±2.45对22.2±5.85 U/L；P = 0.5）和AlkPh（583.4±2.45对472.8±161.5 U/L；P = 0.28）方面无统计学显著差异。
BMI正常的TS患者与超重的TS患者在肝酶水平上无显著差异。
