连续多模态脑成像显示干预后神经血管癫痫反应发生改变。
Continuous multi-modality brain imaging reveals modified neurovascular seizure response after intervention.
作者信息
Ringuette Dene, Jeffrey Melanie A, Dufour Suzie, Carlen Peter L, Levi Ofer
机构信息
The Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario, M5S 3G9, Canada.
Division of Fundamental Neurobiology, Toronto Western Research Institute, 60 Leonard Ave, Toronto, Ontario M5T 2R1, Canada.
出版信息
Biomed Opt Express. 2017 Jan 17;8(2):873-889. doi: 10.1364/BOE.8.000873. eCollection 2017 Feb 1.
Abstract
We developed a multi-modal brain imaging system to investigate the relationship between blood flow, blood oxygenation/volume, intracellular calcium and electrographic activity during acute seizure-like events (SLEs), both before and after pharmacological intervention. Rising blood volume was highly specific to SLE-onset whereas blood flow was more correlated with all eletrographic activity. Intracellular calcium spiked between SLEs and at SLE-onset with oscillation during SLEs. Modified neurovascular and ionic SLE responses were observed after intervention and the interval between SLEs became shorter and more inconsistent. Comparison of artery and vein pulsatile flow suggest proximal interference and greater vascular leakage prior to intervention.
摘要
我们开发了一种多模态脑成像系统，以研究在急性癫痫样发作事件（SLEs）期间及药物干预前后，血流、血氧/血容量、细胞内钙与脑电图活动之间的关系。血容量增加对SLE发作具有高度特异性，而血流与所有脑电图活动的相关性更强。细胞内钙在SLE发作间期和发作开始时飙升，并在SLE发作期间出现振荡。干预后观察到神经血管和离子SLE反应发生改变，SLE发作间期变得更短且更不一致。动脉和静脉搏动血流的比较表明，干预前存在近端干扰和更大的血管渗漏。
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