核编码线粒体蛋白的基因：3'剪接位点共有序列变体的证据。
Genes of nuclear encoded mitochondrial proteins: evidence for a variant of the 3' splice-site consensus sequence.
作者信息
Juretić N, Jaussi R, Mattes U, Christen P
机构信息
Biochemisches Institut, Universität Zürich, Switzerland.
出版信息
Nucleic Acids Res. 1987 Dec 23;15(24):10083-6. doi: 10.1093/nar/15.24.10083.
Abstract
The introns of animal nuclear genes and of viral genes encoding protein possess at their 3' splice-site the consensus sequence (CT)11NTCAG (Mount, S.M. (1982) Nucl. Acids Res. 10, 459-472; Green, M.R. (1986) Ann. Rev. Genet. 20, 671-708). However, the total 39 introns of the 5 imported mitochondrial proteins of higher eucaryotes whose gene structure has been determined to date show a predominance of 44% for base T at position -4. Apparently, a variant consensus sequence, i.e. (CT)11TTCAG, characterizes the genes of nuclear encoded mitochondrial proteins.
摘要
动物核基因以及编码蛋白质的病毒基因的内含子在其3'剪接位点具有共有序列(CT)11NTCAG（蒙特，S.M.（1982年）《核酸研究》10，459 - 472；格林，M.R.（1986年）《遗传学年度评论》20，671 - 708）。然而，迄今为止已确定基因结构的高等真核生物5种导入线粒体蛋白的总共39个内含子在 - 4位置碱基T占比达44%。显然，一种变异的共有序列，即(CT)11TTCAG，是核编码线粒体蛋白基因的特征。
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