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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Kling M A, Kellner C H, Post R M, Cowdry R W, Gardner D L, Coppola R, Putnam F W, Gold P W

Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD.

Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(4):459-81. doi: 10.1016/0278-5846(87)90016-9.

Literature is reviewed that implicates various limbic structures (particularly amygdala and hippocampus) in the modulation of stress-associated neuroendocrine systems. 2. Procaine and related local anesthetics may show a selective proclivity for activating limbic structures. 3. Procaine stimulates ACTH-cortisol and prolactin, but not growth hormone secretion. This pattern is most comparable to that elicited by stimuli which act bilaterally on temporal lobe and limbic areas. 4. Procaine may be a useful agent for helping to elucidate the anatomic and physiologic basis for mood, endocrine, and cognitive dysregulation associated with stress and affective disorders. 5. The endocrine concomitants of limbic activation may have relevance to the course and symptom complex of affective disorders and related psychiatric conditions.

对涉及各种边缘系统结构（特别是杏仁核和海马体）调节应激相关神经内分泌系统的文献进行了综述。2. 普鲁卡因及相关局部麻醉药可能表现出激活边缘系统结构的选择性倾向。3. 普鲁卡因刺激促肾上腺皮质激素 - 皮质醇和催乳素分泌，但不刺激生长激素分泌。这种模式与双侧作用于颞叶和边缘区域的刺激所引发的模式最为相似。4. 普鲁卡因可能是一种有用的药物，有助于阐明与应激和情感障碍相关的情绪、内分泌和认知失调的解剖学和生理学基础。5. 边缘系统激活的内分泌伴随物可能与情感障碍及相关精神疾病的病程和症状复合体相关。

Kling M A, Kellner C H, Post R M, Cowdry R W, Gardner D L, Coppola R, Putnam F W, Gold P W

Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD.

Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(4):459-81. doi: 10.1016/0278-5846(87)90016-9.

Literature is reviewed that implicates various limbic structures (particularly amygdala and hippocampus) in the modulation of stress-associated neuroendocrine systems. 2. Procaine and related local anesthetics may show a selective proclivity for activating limbic structures. 3. Procaine stimulates ACTH-cortisol and prolactin, but not growth hormone secretion. This pattern is most comparable to that elicited by stimuli which act bilaterally on temporal lobe and limbic areas. 4. Procaine may be a useful agent for helping to elucidate the anatomic and physiologic basis for mood, endocrine, and cognitive dysregulation associated with stress and affective disorders. 5. The endocrine concomitants of limbic activation may have relevance to the course and symptom complex of affective disorders and related psychiatric conditions.

对涉及各种边缘系统结构（特别是杏仁核和海马体）调节应激相关神经内分泌系统的文献进行了综述。2. 普鲁卡因及相关局部麻醉药可能表现出激活边缘系统结构的选择性倾向。3. 普鲁卡因刺激促肾上腺皮质激素 - 皮质醇和催乳素分泌，但不刺激生长激素分泌。这种模式与双侧作用于颞叶和边缘区域的刺激所引发的模式最为相似。4. 普鲁卡因可能是一种有用的药物，有助于阐明与应激和情感障碍相关的情绪、内分泌和认知失调的解剖学和生理学基础。5. 边缘系统激活的内分泌伴随物可能与情感障碍及相关精神疾病的病程和症状复合体相关。