白藜芦醇对葡萄糖摄取及代谢的影响
Implications of Resveratrol on Glucose Uptake and Metabolism.
作者信息
León David, Uribe Elena, Zambrano Angara, Salas Mónica
机构信息
Instituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile, Valdivia 509000, Chile.
Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4030000, Chile.
出版信息
Molecules. 2017 Mar 7;22(3):398. doi: 10.3390/molecules22030398.
Resveratrol-a polyphenol of natural origin-has been the object of massive research in the past decade because of its potential use in cancer therapy. However, resveratrol has shown an extensive range of cellular targets and effects, which hinders the use of the molecule for medical applications including cancer and type 2 diabetes. Here, we review the latest advances in understanding how resveratrol modulates glucose uptake, regulates cellular metabolism, and how this may be useful to improve current therapies. We discuss challenges and findings regarding the inhibition of glucose uptake by resveratrol and other polyphenols of similar chemical structure. We review alternatives that can be exploited to improve cancer therapies, including the use of other polyphenols, or the combination of resveratrol with other molecules and their impact on glucose homeostasis in cancer and diabetes.
白藜芦醇——一种天然来源的多酚——在过去十年中一直是大量研究的对象，因为它在癌症治疗中有潜在用途。然而，白藜芦醇已显示出广泛的细胞靶点和作用，这阻碍了该分子在包括癌症和2型糖尿病在内的医学应用中的使用。在这里，我们综述了在理解白藜芦醇如何调节葡萄糖摄取、调节细胞代谢以及这如何有助于改进当前治疗方法方面的最新进展。我们讨论了关于白藜芦醇和其他化学结构相似的多酚抑制葡萄糖摄取的挑战和研究结果。我们综述了可用于改进癌症治疗的替代方法，包括使用其他多酚，或将白藜芦醇与其他分子联合使用，以及它们对癌症和糖尿病中葡萄糖稳态的影响。
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