Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Komturstr. 3a, 60528 Frankfurt, Germany.
Anticancer Agents Med Chem. 2012 Oct 1;12(8):874-9. doi: 10.2174/187152012802650129.
Apoptosis is a critical regulatory mechanism to control tissue homeostasis. Accordingly, too little apoptosis can contribute to cancer. Natural compounds, e.g. polyphenols such as resveratrol, have emerged as promising agents for cancer chemoprevention and therapy, since they interfere with various major signaling cascades that are aberrantly regulated in cancers. For example, resveratrol can antagonize signaling events that prevent apoptosis or support cancer proliferation. Further elucidation of the signaling events that are regulated by resveratrol is anticipated to path the way for the transfer of resveratrol and its derivatives into clinical application for chemoprevention or treatment of human cancers.
细胞凋亡是控制组织动态平衡的关键调节机制。因此，细胞凋亡不足可能会导致癌症。天然化合物，如多酚类物质白藜芦醇，已成为癌症化学预防和治疗的有前途的药物，因为它们可以干扰癌症中异常调节的各种主要信号级联。例如，白藜芦醇可以拮抗阻止细胞凋亡或支持癌症增殖的信号事件。进一步阐明白藜芦醇调节的信号事件，有望为将白藜芦醇及其衍生物转移到人类癌症的化学预防或治疗的临床应用铺平道路。
