Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China.
Eur Rev Med Pharmacol Sci. 2017 Feb;21(4):804-808.
Vascular injuries have been proposed to play a role in cerebral infarction (CI)-induced brain damage. In this study, the expressions of monocyte chemoattractant protein-1 (MCP-1) and vascular endothelial-cadherin (VE-Cadherin) in patients with acute stroke was examined, and the clinical significance was analyzed.
102 patients with acute CI between February 2012 and 2015 were recruited in this study. Among these patients, 43 patients presented with progressive cerebral infarction (PCI) while 59 patients presented with non-progressive cerebral infarction (NPCI). The carotid intima-media thickness (IMT) of all patients was measured by ultrasound as a marker of end-organ damage. Our results showed that 26 patients had normal IMT, 19 patients had a thickening carotid wall and 57 patients presented with a carotid plaque. In our study, 52 healthy volunteers screened by medical checkups in our hospital during the same period were taken as control group. The MCP-1 and VE-cadherin expressions in each group were detected and analyzed.
Compared to the control group, the patients in the experimental group had significantly elevated serum MCP-1 and VE-cadherin levels (p < 0.05). Compared to the NPCI patients, the serum MCP-1 and VE-cadherin levels of the patients with PCI were significantly increased, and the rate of carotid plaque was increased as well, especially in the mixed echo and low echo plaques. Then compared with the patients with normal IMT and thickening carotid wall, the patients with carotid plaques had notably increased MCP-1 and VE-cadherin levels.
For patients with PCI, the serum MCP-1 and VE-cadherin levels were significantly increased. Moreover, serum MCP-1 and VE-cadherin levels were correlated with atherosclerosis and the stability of atherosclerotic plaques in patients with cerebral infarction.
血管损伤被认为在脑梗死（CI）引起的脑损伤中起作用。在这项研究中，检查了急性中风患者单核细胞趋化蛋白-1（MCP-1）和血管内皮钙黏蛋白（VE-Cadherin）的表达，并分析了其临床意义。
本研究纳入了 2012 年 2 月至 2015 年期间的 102 例急性 CI 患者。其中 43 例患者表现为进行性脑梗死（PCI），59 例患者表现为非进行性脑梗死（NPCI）。所有患者均通过超声测量颈动脉内膜中层厚度（IMT）作为终末器官损伤的标志物。结果显示，26 例患者 IMT 正常，19 例患者颈动脉壁增厚，57 例患者存在颈动脉斑块。在本研究中，同期我院体检筛选的 52 例健康志愿者作为对照组。检测并分析了各组的 MCP-1 和 VE-cadherin 表达。
与对照组相比，实验组患者血清 MCP-1 和 VE-cadherin 水平明显升高（p<0.05）。与 NPCI 患者相比，PCI 患者的血清 MCP-1 和 VE-cadherin 水平明显升高，颈动脉斑块的发生率也增加，特别是在混合回声和低回声斑块中。然后与 IMT 正常和颈动脉壁增厚的患者相比，颈动脉斑块患者的 MCP-1 和 VE-cadherin 水平明显升高。
对于 PCI 患者，血清 MCP-1 和 VE-cadherin 水平明显升高。此外，血清 MCP-1 和 VE-cadherin 水平与脑梗死患者的动脉粥样硬化及粥样硬化斑块的稳定性相关。
