Li Zaili, Xin Zaie
Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China.
Exp Ther Med. 2021 Feb;21(2):149. doi: 10.3892/etm.2020.9580. Epub 2020 Dec 16.
The present study aimed to explore the expression and significance of S100 protein β (S100β), cystatin C (CysC), and nuclear factor kappa B (NF-κB) in patients with acute cerebral infarction (ACI). ACI patients (n=120) were selected as the experimental group at Xuzhou Central Hospital from August 2016 to August 2018. Ninety healthy subjects who underwent a physical examination at Xuzhou Central Hospital during the same period were selected as the control group. The expression levels of S-100β, CysC and NF-κB were compared between the two groups. Serum S-100β, CysC and NF-κB levels were compared between ACI patients with different degree of nervous functional defects, different infarct size and different prognosis. ROC curve analysis was used for the diagnosis of ACI by serum S-100β, CysC and NF-κB levels. Serum S-100β, CysC and NF-κB levels in the experimental group were higher than those in the control group (P<0.05). The levels of serum S-100β, CysC and NF-κB in patients with different neurological deficits were significantly different. The levels of serum S-100β, CysC and NF-κB in the severe and medium type infarction group were significantly higher than those in the mild type infarction group (both P<0.05). The levels of serum S-100β, CysC and NF-κB in the severe type infarction group were higher than those in the medium type infarction group (P<0.05). There were significant differences in serum S-100β, CysC and NF-κB levels in patients with different infarct sizes. The levels of serum S-100β, CysC and NF-κB in patients with large and medium size infarction were higher than those in the small size infarction group (both P<0.05). The levels of serum S-100β, CysC and NF-κB in patients with large size infarction were higher than those in patients with medium size infarction (P<0.05). Serum S-100β, CysC and NF-κB levels in patients of the worsening group were significantly higher than those in patients of the non-worsening group. The levels of S-100β, CysC, NF-κB in ACI patients were significantly higher than those in healthy subjects. Increased levels of S-100β, CysC and NF-κB can be used as ideal indexes for diagnosing cerebral infarction and studying the condition.
本研究旨在探讨S100蛋白β（S100β）、胱抑素C（CysC）及核因子κB（NF-κB）在急性脑梗死（ACI）患者中的表达及意义。选取2016年8月至2018年8月在徐州中心医院就诊的ACI患者120例作为实验组。同期在徐州中心医院进行体检的90例健康受试者作为对照组。比较两组S-100β、CysC及NF-κB的表达水平。比较不同神经功能缺损程度、不同梗死灶大小及不同预后的ACI患者血清S-100β、CysC及NF-κB水平。采用ROC曲线分析血清S-100β、CysC及NF-κB水平对ACI的诊断价值。实验组血清S-100β、CysC及NF-κB水平高于对照组（P<0.05）。不同神经功能缺损患者血清S-100β、CysC及NF-κB水平差异有统计学意义。重度和中度梗死组患者血清S-100β、CysC及NF-κB水平显著高于轻度梗死组（均P<0.05）。重度梗死组患者血清S-100β、CysC及NF-κB水平高于中度梗死组（P<0.05）。不同梗死灶大小患者血清S-100β、CysC及NF-κB水平差异有统计学意义。大面积和中面积梗死患者血清S-100β、CysC及NF-κB水平高于小面积梗死组（均P<0.05）。大面积梗死患者血清S-100β、CysC及NF-κB水平高于中面积梗死患者（P<0.05）。病情恶化组患者血清S-100β、CysC及NF-κB水平显著高于病情未恶化组。ACI患者S-100β、CysC、NF-κB水平显著高于健康受试者。S-100β、CysC及NF-κB水平升高可作为诊断脑梗死及病情研究的理想指标。
