Mohamed Mohamed Essam-Elden, Younes Abdel-Khalek, Osmand Ahmed, Mohamed Refaat, Makki Mahmoud, Younis Marwa
a Department of Dermatology , Al Azhar University (Assiut) , Egypt.
b Plastic Surgery Department , Assiut University , Assiut , Egypt.
J Cosmet Laser Ther. 2017 Oct;19(5):290-293. doi: 10.1080/14764172.2017.1303170. Epub 2017 Mar 8.
To compare the efficacy of follicular hair transplantation and mini punch graft in the treatment of stable vitiligo.
Thirty-two patients with stable vitiligo were included in this comparative study. A single patch from each patient was divided into two halves: one half was treated by punch graft, while the other half was treated by follicular hair transplantation followed by excimer light twice weekly, and the outcome was assessed at 0, 1, 3 and 6 months post operatively by photography and quartile scale.
At the final visit, the percentage of improvement of vitiligo in punch graft-treated side was significantly higher than that in follicular hair transplantation-treated side (p < 0.05). Also, repigmentation after punch grafting occurred after a mean period of 2.5 ± 0.5 weeks (range, 2-3 weeks), while after follicular hair transplantation, repigmentation occurred after 5.2 ± 1.9 weeks (range, 5-8 weeks) (p < 0.05). Cobblestone appearance was the most common complication after punch graft; it occurred in 29 patients (90%), while no reported side effects occurred after follicular graft technique.
Punch grafting is more effective than follicular grafting in the treatment of stable vitiligo; however, follicular hair transplantation is cosmetically better, so we recommend it in exposed areas as face.
比较毛囊移植和微小钻孔移植治疗稳定期白癜风的疗效。
本比较研究纳入32例稳定期白癜风患者。将每位患者的单个皮损区分为两半：一半采用钻孔移植治疗，另一半采用毛囊移植治疗，随后每周进行两次准分子光治疗，并在术后0、1、3和6个月通过拍照和四分位数量表评估疗效。
在最后一次随访时，钻孔移植治疗侧白癜风改善的百分比显著高于毛囊移植治疗侧（p < 0.05）。此外，钻孔移植后色素再生平均发生在2.5±0.5周（范围2 - 3周），而毛囊移植后色素再生发生在5.2±1.9周（范围5 - 8周）（p < 0.05）。鹅卵石样外观是钻孔移植后最常见的并发症；29例患者（90%）出现该并发症，而毛囊移植技术后未报告有副作用发生。
在治疗稳定期白癜风方面，钻孔移植比毛囊移植更有效；然而，毛囊移植在美容效果上更好，因此我们建议在面部等暴露部位使用。
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