Rey H G, Anner B M
Département de pharmacologie, Centre médical universitaire, Genéve.
Schweiz Med Wochenschr. 1987 Nov 28;117(48):1881-7.
It has been well established that the Na+,K+-ATPase is the pharmacological receptor of cardiac glycosides. One or several endogenous analogues of these digitalis compounds have been shown to interfere with radioimmunoassays (RIA). Given the low therapeutic range of the steroid cardiotonics, such interference must be taken into consideration. The present review briefly describes the digitalis receptor and discusses monitoring by RIA of patients treated with cardiac glycosides. Finally, the putative origin and chemical nature of this (these) endogenous digoxin-like factor(s) are presented in detail.
钠钾ATP酶作为强心苷的药理学受体已得到充分证实。这些洋地黄类化合物的一种或几种内源性类似物已被证明会干扰放射免疫分析（RIA）。鉴于类固醇强心剂的治疗范围较窄，必须考虑这种干扰。本综述简要描述了洋地黄受体，并讨论了对接受强心苷治疗患者的放射免疫分析监测。最后，详细介绍了这种（这些）内源性地高辛样因子的假定来源和化学性质。
