Trinh Sonya A, Angarone Michael P
Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Transpl Infect Dis. 2017 Jun;19(3). doi: 10.1111/tid.12689. Epub 2017 Apr 13.
Purpureocillium lilacinum is an emerging pathogenic mold among immunocompromised hosts that causes cutaneous infections related to skin breakdown. We present the first reported case of P. lilacinum tattoo-related skin infection, to our knowledge. A kidney transplant recipient recently treated for acute cellular rejection presented with skin papules overlying a tattoo. Diagnosis was confirmed on culture, histology, and 18S ribosomal RNA polymerase chain reaction. The morphological features on culture characteristic of P. lilacinum included violet colonies on malt extract agar, long tapering brush-like phialides, and elliptical conidia attached in chains. P. lilacinum has intrinsic resistance to many antifungal agents including amphotericin B, but voriconazole and posaconazole have good in vitro activity. The patient was treated with voriconazole with subsequent resolution of the papules after 3 months of therapy.
淡紫拟青霉是免疫功能低下宿主中一种新出现的致病霉菌，可引起与皮肤破损相关的皮肤感染。据我们所知，我们报告了首例与纹身相关的淡紫拟青霉皮肤感染病例。一名因急性细胞排斥反应近期接受治疗的肾移植受者，其纹身部位出现皮肤丘疹。通过培养、组织学检查和18S核糖体RNA聚合酶链反应确诊。淡紫拟青霉在培养物上的形态学特征包括在麦芽提取物琼脂上形成紫色菌落、长而逐渐变细的刷状瓶梗以及呈链状附着的椭圆形分生孢子。淡紫拟青霉对包括两性霉素B在内的许多抗真菌药物具有固有抗性，但伏立康唑和泊沙康唑具有良好的体外活性。该患者接受了伏立康唑治疗，治疗3个月后丘疹消退。
