Min Kyueng-Whan, Kim Dong-Hoon, Son Byoung Kwan, Kim Dong Hyun, Kim Eun-Kyung, Seo Jinwon, Ahn Sang Bong, Jo Yun Ju, Park Young Sook, Ha Junghoon
Department of Pathology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Republic of Korea.
Eur Surg Res. 2017;58(3-4):158-168. doi: 10.1159/000448945. Epub 2017 Mar 9.
The heterogeneity of gastric cancer makes the identification of potential prognostic indicators particularly important. The Ki67 and BCL2 proteins are known prognostic markers for different types of cancer. Ki67 is associated with cell proliferation, whereas BCL2 has antiproliferative roles. A combined marker based on these opposite functions might provide improved prognostic information in gastric cancer.
Ki67 and BCL2 expression was assessed in 276 gastric adenocarcinoma tissue microarrays. A Ki67/BCL2 index based on the relative expression of each protein was divided into low- and high-risk groups using receiver operating characteristic curves.
A high Ki67/BCL2 index significantly correlated with advanced stage, recurrence, intestinal type, high histologic grade, and lymphatic and perineural invasion (all p < 0.05). Univariate and multivariate analyses revealed a significant relationship between disease-free or overall survival and the Ki67/BCL2 index in intestinal-type gastric cancer (all p < 0.05).
A combined marker using Ki67 and BCL2 could be a useful indicator for predicting survival in patients with intestinal-type gastric cancer.
胃癌的异质性使得识别潜在的预后指标尤为重要。Ki67和BCL2蛋白是不同类型癌症已知的预后标志物。Ki67与细胞增殖相关，而BCL2具有抗增殖作用。基于这些相反功能的联合标志物可能为胃癌提供更好的预后信息。
在276个胃腺癌组织微阵列中评估Ki67和BCL2的表达。使用受试者工作特征曲线将基于每种蛋白相对表达的Ki67/BCL2指数分为低风险和高风险组。
高Ki67/BCL2指数与晚期、复发、肠型、高组织学分级以及淋巴管和神经周围侵犯显著相关（所有p<0.05）。单因素和多因素分析显示，肠型胃癌的无病生存期或总生存期与Ki67/BCL2指数之间存在显著关系（所有p<0.05）。
使用Ki67和BCL2的联合标志物可能是预测肠型胃癌患者生存的有用指标。
