Serviço de Neurologia, Centro Hospitalar do Porto, Hospital de Santo António, Porto, Portugal.
Servico de Neurologia, Centro Hospitalar do Porto, Hospital de Santo António, Porto, Portugal/Unidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
Mult Scler. 2018 Mar;24(3):350-353. doi: 10.1177/1352458517692885. Epub 2017 Feb 1.
Autoimmune hepatitis (AIH) is a rare and chronic inflammatory disorder associated with extrahepatic autoimmune diseases, including, infrequently, multiple sclerosis (MS). Short Reports: We report five cases of MS and AIH association. One patient developed AIH while under interferon beta-1b and the remaining while off disease-modifying therapy, although after methylprednisolone bolus in three. All presented a liver biopsy compatible with AIH. Hepatitis resolution was achieved with immunosuppressive treatment, but one patient died after a fulminant hepatitis requiring liver transplant.
A thorough review of published cases supports this clear, although rare, association and a liver biopsy should be considered in AIH suspected cases.
自身免疫性肝炎（AIH）是一种罕见的慢性炎症性疾病，与肝外自身免疫性疾病有关，包括不常见的多发性硬化症（MS）。短篇报道：我们报告了五例 MS 与 AIH 相关的病例。一名患者在接受干扰素β-1b 治疗时出现 AIH，其余三名患者在停用疾病修正治疗后出现 AIH，尽管在其中三名患者中使用了甲基强的松龙冲击治疗。所有患者的肝脏活检均符合 AIH 的特征。免疫抑制治疗后肝炎得到缓解，但一名患者因暴发性肝炎需要肝移植而死亡。
对已发表病例的全面回顾支持了这种明确的、尽管罕见的关联，在疑似 AIH 的病例中应考虑进行肝活检。
