Anadure Ravi, Narayanan Coimbatore, Varadraj Govindraj, Nandeesh Bevinahalli
Senior Advisor, Department of Medicine and Neurology, INHS ASVINI , Mumbai, Maharashtra, India .
Senior Consultant and Director General, Department of Medicine, Armed Forces Medical Service , New Delhi, India .
J Clin Diagn Res. 2017 Jan;11(1):OD01-OD03. doi: 10.7860/JCDR/2017/22252.9149. Epub 2017 Jan 1.
Mononeuritis multiplex is a common manifestation of many illnesses which includes Hansen's disease and certain types of systemic vasculitis. The Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis (AAV) is a group of rare diseases which show typical characteristic inflammatory cell infiltration and blood vessel wall necrosis. AAV syndromes include Granulomatosis with Polyangiitis (GPA), Microscopic Polyangiitis (MPA) and Eosinophilic Granulomatosis with Polyangiitis (EGPA). We describe a patient who presented with mononeuritis multiplex and had features of overlap between EGPA and MPA. The patient was treated with standard regimen of steroids and pulsed cyclophosphamide and she achieved excellent clinical remission.
多发性单神经炎是许多疾病的常见表现，包括麻风病和某些类型的系统性血管炎。抗中性粒细胞胞浆抗体（ANCA）相关血管炎（AAV）是一组罕见疾病，表现为典型的特征性炎症细胞浸润和血管壁坏死。AAV综合征包括肉芽肿性多血管炎（GPA）、显微镜下多血管炎（MPA）和嗜酸性肉芽肿性多血管炎（EGPA）。我们描述了一名患有多发性单神经炎且具有EGPA和MPA重叠特征的患者。该患者接受了标准的类固醇和脉冲环磷酰胺治疗方案，临床获得了极佳的缓解。
