Köhler Stephan, Ouahrani-Bettache Safia, Winum Jean-Yves
a Institut de Recherche en Infectiologie de Montpellier (IRIM) UMR 9004, Université de Montpellier, CNRS , Montpellier , France.
b Institut des Biomolécules Max Mousseron (IBMM) UMR 5247 CNRS, ENSCM, Université de Montpellier, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier , Montpellier , France.
J Enzyme Inhib Med Chem. 2017 Dec;32(1):683-687. doi: 10.1080/14756366.2017.1295451.
Carbonic anhydrases have started to emerge as new potential antibacterial targets for several pathogens. Two β-carbonic anhydrases, denominated bsCA I and bsCA II, have been isolated and characterized from the bacterial pathogen Brucella suis, the causative agent of brucellosis or Malta fever. These enzymes have been investigated in detail and a wide range of classical aromatic and heteroaromatic sulfonamides as well as carbohydrate-based compounds have been found to inhibit selectively and efficiently Brucella suis carbonic anhydrases. Inhibition of these metalloenzymes constitutes a novel approach for the potential development of new anti-Brucella agents. This review aims at discussing the recent literature on this topic.
碳酸酐酶已开始成为几种病原体新的潜在抗菌靶点。已从布鲁氏菌病或马耳他热的病原体猪布鲁氏菌中分离并鉴定出两种β-碳酸酐酶，分别命名为bsCA I和bsCA II。对这些酶进行了详细研究，发现多种经典的芳香族和杂芳香族磺胺类化合物以及基于碳水化合物的化合物可选择性且有效地抑制猪布鲁氏菌碳酸酐酶。抑制这些金属酶构成了开发新型抗布鲁氏菌药物的一种新方法。本综述旨在讨论有关该主题的最新文献。
