Ozawa Yoko, Yamamoto Hiroshi, Yasuo Masanori, Takahashi Hidekazu, Tateishi Kazunari, Ushiki Atsuhito, Kawakami Satoshi, Fujinaga Yasunari, Asaka Shiho, Sano Kenji, Takayama Hiroshi, Imamura Hiroshi, Hanaoka Masayuki
First Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Department of Radiology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Respir Investig. 2017 Mar;55(2):176-180. doi: 10.1016/j.resinv.2016.10.003. Epub 2016 Nov 23.
We herein report on two middle-aged men with TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis or renal failure, and organomegaly) syndrome, a unique clinicopathological variant of multicentric Castleman׳s disease recently proposed in Japan. Strikingly similar anterior mediastinal fat swellings with soft tissue density were observed in the patients on chest computed tomography. In TAFRO syndrome, bilateral pleural effusion and slight lymph node swelling are common in the thoracic region; however, anterior mediastinal lesions have not been previously observed. Although the mechanisms of anterior mediastinal lesions have not been defined, these lesions seem to have a close relationship with TAFRO syndrome.
我们在此报告两例患有TAFRO（血小板减少、全身性水肿、发热、网状纤维增生或肾衰竭以及器官肿大）综合征的中年男性患者，TAFRO综合征是日本最近提出的多中心Castleman病的一种独特临床病理变体。胸部计算机断层扫描显示，患者前纵隔脂肪肿胀且软组织密度惊人地相似。在TAFRO综合征中，双侧胸腔积液和轻微淋巴结肿大在胸部区域较为常见；然而，此前尚未观察到前纵隔病变。尽管前纵隔病变的机制尚未明确，但这些病变似乎与TAFRO综合征密切相关。
