Picard Fabien, Doucet Serge, Asgar Anita W
Interventional cardiology division, department of medicine, Montreal heart institute, université de Montréal, 5000 Bélanger, H1T 1C8 Montréal, QC, Canada; Interventional cardiology department, Cochin hospital, Assistance publique-Hôpitaux de Paris, Paris, France.
Interventional cardiology division, department of medicine, Montreal heart institute, université de Montréal, 5000 Bélanger, H1T 1C8 Montréal, QC, Canada.
Arch Cardiovasc Dis. 2017 Apr;110(4):259-272. doi: 10.1016/j.acvd.2017.01.005. Epub 2017 Mar 6.
The drug-coated balloon (DCB) has emerged as an additional tool in the arsenal of interventional cardiology devices; it delivers antiproliferative drugs to local arterial tissue by single prolonged coated balloon angioplasty inflation, and prevents restenosis, leaving no implant behind. This strategy theoretically decreases the risk of late inflammatory response to device components, without preventing positive remodelling. DCBs, when used carefully and with a good technique, may have a role in the treatment of lesion subsets, such as in-stent restenosis, small vessel disease or side branch bifurcations, in which the implantation of a drug-eluting stent is not desirable or is technically challenging. Using the latest evidence regarding the effectiveness of the currently available DCBs, this review will discuss the rationale for DCB use, and the effectiveness of DCBs in different clinical and lesion settings, and will give practical tips for their correct use in everyday clinical practice.
药物涂层球囊（DCB）已成为介入心脏病学器械库中的一种额外工具；它通过单次延长涂层球囊血管成形术充盈将抗增殖药物输送至局部动脉组织，并预防再狭窄，且不遗留植入物。从理论上讲，这种策略可降低对器械组件发生迟发性炎症反应的风险，同时不阻碍正向重塑。若谨慎使用且技术娴熟，DCB可能在某些病变亚组的治疗中发挥作用，例如支架内再狭窄、小血管疾病或分支分叉病变，在这些病变中，植入药物洗脱支架不可取或在技术上具有挑战性。利用有关当前可用DCB有效性的最新证据，本综述将讨论使用DCB的基本原理、DCB在不同临床和病变情况下的有效性，并给出在日常临床实践中正确使用DCB的实用提示。
