Shoupe D, Mishell D R, Page M A, Madkour H, Spitz I M, Lobo R A
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.
Am J Obstet Gynecol. 1987 Dec;157(6):1421-6. doi: 10.1016/s0002-9378(87)80236-3.
RU 486, a synthetic steroid with antiprogesterone receptor activity, was used to investigate the importance of progesterone on gonadotropin secretory dynamics in the midcycle of the normal menstrual cycle. Six normally cycling women were followed for three consecutive cycles. During each cycle, blood samples were obtained beginning on day 10 and continued until menses. After a control cycle, 100 mg RU 486 was given orally between days 10 and 17. The patients were followed for a posttreatment cycle with no medication. When RU 486 was given before the midcycle, the luteinizing hormone surge was delayed by 15.0 +/- 2.1 days after ingestion of the last pill, resulting in cycles of 40.6 +/- 2.6 compared with 28.0 +/- 2.3 days (p less than 0.01). During RU 486 administration and at the time a normal luteinizing hormone surge was anticipated, an attenuated luteinizing hormone/follicle-stimulating hormone surge was noted that was not followed by a rise in progesterone. After the attenuated surge a normal luteinizing hormone/follicle-stimulating hormone level occurred, with a normal rise in progesterone. Estradiol levels during RU 486 administration decreased during treatment, indicating a possible direct action of RU 486 on the ovary.
RU 486是一种具有抗孕激素受体活性的合成类固醇，被用于研究孕激素对正常月经周期中期促性腺激素分泌动态的重要性。六名月经周期正常的女性连续三个周期接受跟踪观察。在每个周期中，从第10天开始采集血样，一直持续到月经来潮。在一个对照周期后，于第10天至第17天之间口服100毫克RU 486。患者在无药物治疗的情况下接受一个治疗后周期的跟踪观察。当中周期前给予RU 486时，促黄体生成素峰在服用最后一片药后延迟了15.0±2.1天，导致周期为40.6±2.6天，而对照周期为28.0±2.3天（p<0.01）。在服用RU 486期间以及预期出现正常促黄体生成素峰时，观察到促黄体生成素/促卵泡生成素峰减弱，且之后孕激素没有升高。在减弱的峰之后，出现了正常的促黄体生成素/促卵泡生成素水平，同时孕激素正常升高。服用RU 486期间，雌二醇水平在治疗过程中下降，表明RU 486可能对卵巢有直接作用。
