Krishnan K R, Manepalli A N, Ritchie J C, Rayasam K, Melville M L, Thorner M O, Rivier J E, Vale W W, Nemeroff C B
Duke University Medical Center, Department of Psychiatry, Durham, NC 27710.
Peptides. 1988;9 Suppl 1:113-6. doi: 10.1016/0196-9781(88)90234-3.
A blunted growth hormone (GH) response to clonidine and other pharmacologic stimuli has been reported in patients with depression. This blunted growth hormone response to clonidine has led to the speculation that there is a central alpha-2 adrenergic receptor subsensitivity in depression. This hypothesis is based on the assumption that the pituitary somatotroph response to growth hormone-releasing factor (GHRF) is not altered in depression. In the present preliminary study, the somatotroph response to GHRF in depressed patients and normal controls has been evaluated in four depressed patients and four age- and sex-matched controls. The GH response to GRF is highly variable both in normal individuals and in the depressed patients studied. Larger numbers of patients and controls must be studied before any definitive conclusions can be drawn about GH responses to GRF in depressed patients.
据报道，抑郁症患者对可乐定和其他药理学刺激的生长激素（GH）反应迟钝。这种对可乐定的生长激素反应迟钝引发了一种推测，即抑郁症患者存在中枢α-2肾上腺素能受体敏感性降低。该假设基于这样一种假定，即抑郁症患者垂体生长激素细胞对生长激素释放因子（GHRF）的反应未发生改变。在本项初步研究中，对4名抑郁症患者和4名年龄及性别匹配的对照者评估了生长激素细胞对GHRF的反应。正常个体和所研究的抑郁症患者中，GH对GRF的反应都高度可变。在能够就抑郁症患者GH对GRF的反应得出任何确定性结论之前，必须研究更多数量的患者和对照者。
