Aydemir Bulent
Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
North Clin Istanb. 2017 Jan 25;3(3):194-200. doi: 10.14744/nci.2016.60352. eCollection 2016.
Thymoma is a standard epithelial tumor. Though it is rare, it constitutes 50% of anterior mediastinal masses. Variety of immunological diseases may accompany thymoma; however, myasthenia gravis (MG) is the most frequently associated paraneoplastic syndrome. Most effective treatment for thymoma is complete surgical resection. In this study, impact of MG on prognosis of thymoma cases was examined.
Records of 61 patients who underwent surgery with diagnosis of thymoma between January 2003 and September 2016 were retrospectively reviewed. All cases were analyzed for data related to age, gender, complaint, localization of lesion, surgical procedure, histopathological diagnosis, stage, MG, and long-term follow-up results.
Total of 58 cases were included in the study. Of those, 37 patients were male and 21 were female. Mean age was 48 years. While 24 cases of thymoma were accompanied by MG, 34 cases were not. Duration of follow-up ranged from 1 month to 155 months.
It was found that in group with MG, 5-year survival rate was 87.5% while it was 82.4% in group without MG. Despite longer duration of survival in group of thymoma associated with MG, there was no significant statistical difference between groups (p=0.311).
胸腺瘤是一种典型的上皮性肿瘤。虽然它很罕见，但它占前纵隔肿块的50%。多种免疫性疾病可能伴发胸腺瘤；然而，重症肌无力（MG）是最常伴发的副肿瘤综合征。胸腺瘤最有效的治疗方法是完整手术切除。在本研究中，研究了MG对胸腺瘤患者预后的影响。
回顾性分析2003年1月至2016年9月间61例诊断为胸腺瘤并接受手术治疗患者的记录。分析所有病例的年龄、性别、主诉、病变部位、手术方式、组织病理学诊断、分期、MG及长期随访结果等相关数据。
本研究共纳入58例病例。其中，男性37例，女性21例。平均年龄48岁。24例胸腺瘤伴发MG，34例未伴发。随访时间为1个月至155个月。
发现伴发MG组的5年生存率为87.5%，未伴发MG组为82.4%。尽管伴发MG的胸腺瘤组生存时间更长，但两组间无显著统计学差异（p=0.311）。
