Sava Florentina, Toldi Gergely, Treszl András, Hajdú Júlia, Harmath Ágnes, Rigó János, Tulassay Tivadar, Vásárhelyi Barna
First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
First Department of Pediatrics, Semmelweis University, Budapest, Hungary.
Am J Reprod Immunol. 2017 Jun;77(6). doi: 10.1111/aji.12659. Epub 2017 Mar 9.
To address the hypothesis that pre-eclampsia (PE) impacts the fetal immune system, we investigated the prevalence of distinct immune cell subsets along with plasma cortisol and cytokine levels in pre-term newborns of PE mothers.
Cord blood and peripheral blood samples on the 1st, 3rd and 7th postnatal days of life were collected from 14 pre-term infants affected by PE and 14 non-PE pregnancies. We measured plasma cortisol and cytokine levels with immunoassays and assessed the prevalence of T, NK and DC subsets using flow cytometry.
The prevalence of CD4+ cells was lower in PE infants, while that of memory T cells was higher. Myeloid DCs had a lower prevalence in PE neonates. Cytokine and cortisol levels were lower in PE neonates.
Our observations show that PE pregnancies are associated with altered newborn immune status during the first week of life.
为验证子痫前期（PE）会影响胎儿免疫系统这一假说，我们调查了PE母亲所生早产儿中不同免疫细胞亚群的患病率以及血浆皮质醇和细胞因子水平。
收集了14例受PE影响的早产儿和14例非PE妊娠的新生儿出生后第1天、第3天和第7天的脐带血和外周血样本。我们用免疫测定法测量了血浆皮质醇和细胞因子水平，并使用流式细胞术评估了T、NK和DC亚群的患病率。
PE婴儿中CD4+细胞的患病率较低，而记忆T细胞的患病率较高。髓样DC在PE新生儿中的患病率较低。PE新生儿的细胞因子和皮质醇水平较低。
我们的观察结果表明，PE妊娠与出生后第一周新生儿免疫状态的改变有关。
