Ilyas Asim, Shah Munir H
a Department of Chemistry , Quaid-i-Azam University , Islamabad , Pakistan.
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2017 May 12;52(6):571-579. doi: 10.1080/10934529.2017.1284438. Epub 2017 Feb 28.
The present study was designed to investigate the role of selected essential and toxic metals in the onset/prognosis of valvular heart disease (VHD). Nitric acid-perchloric acid based wet digestion procedure was used for the quantification of the metals by flame atomic absorption spectrophotometry. Comparative appraisal of the data revealed that average levels of Cd, Co, Cr, Fe, K, Li, Mn and Zn were significantly higher in blood of VHD patients, while the average concentration of Ca was found at elevated level in controls (P < 0.05). However, Cu, Mg, Na, Sr and Pb depicted almost comparable levels in the blood of both donor groups. The correlation study revealed significantly different mutual associations among the metals in the blood of VHD patients compared with the controls. Multivariate statistical methods showed substantially divergent grouping of the metals for the patients and controls. Some significant differences in the metal concentrations were also observed with gender, abode, dietary/smoking habits and occupations of both donor groups. Overall, the study demonstrated that disproportions in the concentrations of essential/toxic metals in the blood are involved in pathogenesis of the disease.
本研究旨在调查特定必需金属和有毒金属在心脏瓣膜病（VHD）发病/预后中的作用。采用基于硝酸 - 高氯酸的湿式消解程序，通过火焰原子吸收分光光度法对金属进行定量分析。对数据的比较评估显示，VHD患者血液中镉（Cd）、钴（Co）、铬（Cr）、铁（Fe）、钾（K）、锂（Li）、锰（Mn）和锌（Zn）的平均水平显著高于对照组，而对照组中钙（Ca）的平均浓度则处于较高水平（P < 0.05）。然而，铜（Cu）、镁（Mg）、钠（Na）、锶（Sr）和铅（Pb）在两组供血者血液中的水平几乎相当。相关性研究表明，与对照组相比，VHD患者血液中金属之间的相互关联存在显著差异。多变量统计方法显示，患者和对照组的金属分组存在很大差异。在两组供血者中，还观察到金属浓度在性别、居住地址、饮食/吸烟习惯和职业方面存在一些显著差异。总体而言，该研究表明血液中必需金属/有毒金属浓度的失衡与该疾病的发病机制有关。
