Liberal Francisco D C Guerra, Tavares Adriana Alexandre S, Tavares João Manuel R S
a Faculdade de Engenharia , Instituto de Ciência e Inovação em Engenharia Mecânica e Engenharia Industrial, Universidade do Porto , Porto , Portugal.
Int J Radiat Biol. 2017 Jun;93(6):627-636. doi: 10.1080/09553002.2017.1294274. Epub 2017 Mar 3.
Computational simulation is a simple and practical way to study and to compare a variety of radioisotopes for different medical applications, including the palliative treatment of bone metastases. This study aimed to evaluate and compare cellular effects modelled for different radioisotopes currently in use or under research for treatment of bone metastases using computational methods.
Computational models were used to estimate the radiation-induced cellular effects (Virtual Cell Radiobiology algorithm) post-irradiation with selected particles emitted by Strontium-89 (Sr), Samarium-153 (Sm), Lutetium-177 (Lu), and Radium-223 (Ra).
Cellular kinetics post-irradiation using Sr β particles, Sm βparticles, Lu βparticles and Ra α particles showed that the cell response was dose- and radionuclide-dependent. Lu beta minus particles and, in particular, Ra alpha particles, yielded the lowest survival fraction of all investigated particles.
Ra alpha particles induced the highest cell death of all investigated particles on metastatic prostate cells in comparison to irradiation with βradionuclides, two of the most frequently used radionuclides in the palliative treatment of bone metastases in clinical routine practice. Moreover, the data obtained suggest that the used computational methods might provide some perception about cellular effects following irradiation with different radionuclides.
计算模拟是一种简单实用的方法，可用于研究和比较多种用于不同医学应用的放射性同位素，包括骨转移瘤的姑息治疗。本研究旨在使用计算方法评估和比较目前正在使用或正在研究用于治疗骨转移瘤的不同放射性同位素所模拟的细胞效应。
使用计算模型来估计在受到锶 - 89（Sr）、钐 - 153（Sm）、镥 - 177（Lu）和镭 - 223（Ra）发射的选定粒子照射后辐射诱导的细胞效应（虚拟细胞放射生物学算法）。
使用Srβ粒子、Smβ粒子、Luβ粒子和Raα粒子照射后的细胞动力学表明，细胞反应取决于剂量和放射性核素。Luβ - 粒子，特别是Raα粒子，在所有研究的粒子中产生了最低的存活分数。
与临床常规实践中骨转移瘤姑息治疗最常用的两种放射性核素β放射性核素照射相比，Raα粒子在所有研究的粒子中对转移性前列腺细胞诱导的细胞死亡最高。此外，获得的数据表明，所使用的计算方法可能会提供一些关于不同放射性核素照射后细胞效应的认识。
