EANM 骨转移核素治疗指南：β发射性核素。
EANM guidelines for radionuclide therapy of bone metastases with beta-emitting radionuclides.
机构信息
Nuclear Medicine and Endocrine Oncology Department, Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland.
Clinic for Nuclear Medicine, University Hospital Essen, Essen, Germany.
出版信息
Eur J Nucl Med Mol Imaging. 2018 May;45(5):846-859. doi: 10.1007/s00259-018-3947-x. Epub 2018 Feb 16.
Abstract
The skeleton is the most common metastatic site in patients with advanced cancer. Pain is a major healthcare problem in patients with bone metastases. Bone-seeking radionuclides that selectively accumulate in the bone are used to treat cancer-induced bone pain and to prolong survival in selected groups of cancer patients. The goals of these guidelines are to assist nuclear medicine practitioners in: (a) evaluating patients who might be candidates for radionuclide treatment of bone metastases using beta-emitting radionuclides such as strontium-89 (Sr), samarium-153 (Sm) lexidronam (Sm-EDTMP), and phosphorus-32 (P) sodium phosphate; (b) performing the treatments; and
摘要
骨骼是晚期癌症患者中最常见的转移部位。疼痛是骨转移患者的主要医疗保健问题。骨靶向放射性核素选择性地积聚在骨骼中，用于治疗癌症引起的骨痛，并延长某些癌症患者群体的生存期。这些指南的目的是协助核医学从业者：(a) 评估可能适合使用β发射放射性核素（如锶-89（Sr）、钐-153（Sm）依替膦酸（Sm-EDTMP）和磷-32（P）磷酸钠）治疗骨转移的患者；(b) 进行治疗。
相似文献
1
EANM guidelines for radionuclide therapy of bone metastases with beta-emitting radionuclides.EANM 骨转移核素治疗指南：β发射性核素。
Eur J Nucl Med Mol Imaging. 2018 May;45(5):846-859. doi: 10.1007/s00259-018-3947-x. Epub 2018 Feb 16.
2
Strontium and samarium therapy for bone metastases from prostate carcinoma.
Australas Radiol. 1999 Nov;43(4):476-9. doi: 10.1046/j.1440-1673.1999.00716.x.
3
[Radionuclide therapy for painful bone metastases].[放射性核素治疗疼痛性骨转移瘤]
Wiad Lek. 2004;57(5-6):280-3.
4
Radiopharmaceuticals for Palliation of Bone Pain in Patients with Castration-resistant Prostate Cancer Metastatic to Bone: A Systematic Review.用于缓解去势抵抗性前列腺癌骨转移患者骨痛的放射性药物：系统评价。
Eur Urol. 2016 Sep;70(3):416-26. doi: 10.1016/j.eururo.2015.09.005. Epub 2015 Sep 19.
5
Radionuclides for metastatic bone pain palliation: a need for rational re-evaluation in the new millennium.
J Nucl Med. 2000 Apr;41(4):688-91.
6
Prospective evaluation of samarium-153-EDTMP radionuclide treatment for bone metastases in patients with hormone-refractory prostate cancer.钐-153-乙二胺四甲基膦酸（Sm-153-EDTMP）放射性核素治疗激素难治性前列腺癌骨转移患者的前瞻性评估
Urol Int. 2007;78(1):50-7. doi: 10.1159/000096935.
7
Samarium lexidronam (153Sm-EDTMP): skeletal radiation for osteoblastic bone metastases and osteosarcoma.钐-153 乙二胺四甲基膦酸（153Sm-EDTMP）：用于成骨性骨转移瘤和骨肉瘤的骨骼放疗
Expert Rev Anticancer Ther. 2007 Nov;7(11):1517-27. doi: 10.1586/14737140.7.11.1517.
8
89Sr versus 153Sm-EDTMP: comparison of treatment efficacy of painful bone metastases in prostate and breast carcinoma.89锶与153钐-乙二胺四甲撑膦酸：前列腺癌和乳腺癌疼痛性骨转移治疗效果的比较
Nucl Med Commun. 2007 Apr;28(4):245-50. doi: 10.1097/MNM.0b013e32805b72a0.
9
High-dose samarium-153 ethylene diamine tetramethylene phosphonate: low toxicity of skeletal irradiation in patients with osteosarcoma and bone metastases.高剂量钐-153 乙二胺四亚甲基膦酸盐：骨肉瘤和骨转移患者骨骼照射的低毒性
J Clin Oncol. 2002 Jan 1;20(1):189-96. doi: 10.1200/JCO.2002.20.1.189.
10
Combined use of zoledronic acid and 153Sm-EDTMP in hormone-refractory prostate cancer patients with bone metastases.唑来膦酸与153Sm-EDTMP联合用于激素难治性骨转移前列腺癌患者
Eur J Nucl Med Mol Imaging. 2008 Apr;35(4):756-65. doi: 10.1007/s00259-007-0659-z. Epub 2007 Dec 22.
引用本文的文献
1
[Lu]Lu-EDTMP -a bone pain palliating agent: pharmacokinetics, biodistribution, safety profile and clinical evaluation in osseous metastatic patients.[镥] 镥-乙二胺四甲基膦酸 - 一种缓解骨痛的药物：骨转移患者的药代动力学、生物分布、安全性概况及临床评估
Eur J Nucl Med Mol Imaging. 2025 Apr 2. doi: 10.1007/s00259-025-07218-x.
2
Advanced targeted microsphere embolization for arteriovenous malformations: state-of-the-art and future directions.用于动静脉畸形的先进靶向微球栓塞术：现状与未来方向。
Neuroradiology. 2025 Apr;67(4):1009-1022. doi: 10.1007/s00234-025-03584-3. Epub 2025 Mar 15.
3
Immunotherapy in the Battle Against Bone Metastases: Mechanisms and Emerging Treatments.抗击骨转移中的免疫疗法：作用机制与新兴治疗方法
Pharmaceuticals (Basel). 2024 Nov 26;17(12):1591. doi: 10.3390/ph17121591.
4
Superscan Pattern on Bone Scintigraphy: A Comprehensive Review.骨闪烁显像中的超级骨显像模式：综述
Diagnostics (Basel). 2024 Oct 6;14(19):2229. doi: 10.3390/diagnostics14192229.
5
Developments in radionanotheranostic strategies for precision diagnosis and treatment of prostate cancer.用于前列腺癌精准诊断与治疗的放射性核素诊疗策略的进展
EJNMMI Radiopharm Chem. 2024 Aug 24;9(1):62. doi: 10.1186/s41181-024-00295-7.
6
Localized radiotherapy of solid tumors using radiopharmaceutical loaded implantable system: insights from a mathematical model.使用载有放射性药物的可植入系统对实体瘤进行局部放射治疗：来自数学模型的见解
Front Oncol. 2024 Feb 26;14:1320371. doi: 10.3389/fonc.2024.1320371. eCollection 2024.
7
Emulsion Technology in Nuclear Medicine: Targeted Radionuclide Therapies, Radiosensitizers, and Imaging Agents.核医学中的乳剂技术：靶向放射性核素治疗、增敏剂和显像剂。
Int J Nanomedicine. 2023 Aug 3;18:4449-4470. doi: 10.2147/IJN.S416737. eCollection 2023.
8
Current status of contemporary diagnostic radiotracers in the management of breast cancer: first steps toward theranostic applications.当代诊断性放射性示踪剂在乳腺癌治疗中的现状：向诊疗一体化应用迈出的第一步。
EJNMMI Res. 2023 May 17;13(1):43. doi: 10.1186/s13550-023-00995-2.
9
A Multimodal Clinical Approach for the Treatment of Bone Metastases in Solid Tumors.一种用于治疗实体瘤骨转移的多模式临床方法。
Anesth Pain Med. 2022 Jun 21;12(3):e126333. doi: 10.5812/aapm-126333. eCollection 2022 Jun.
10
Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials.前列腺癌引发的骨痛：病理生物学、当前治疗方法及近期临床试验的疼痛反应
Discov Oncol. 2022 Oct 18;13(1):108. doi: 10.1007/s12672-022-00569-z.
本文引用的文献
1
EANM guideline for radionuclide therapy with radium-223 of metastatic castration-resistant prostate cancer.EANM 指南：镭-223 治疗转移性去势抵抗性前列腺癌。
Eur J Nucl Med Mol Imaging. 2018 May;45(5):824-845. doi: 10.1007/s00259-017-3900-4. Epub 2017 Dec 12.
2
Consequences of radiopharmaceutical extravasation and therapeutic interventions: a systematic review.放射性药物外渗的后果及治疗干预：一项系统评价
Eur J Nucl Med Mol Imaging. 2017 Jul;44(7):1234-1243. doi: 10.1007/s00259-017-3675-7. Epub 2017 Mar 16.
3
Role of radiation therapy in palliative care of the patient with cancer.放射治疗在癌症患者姑息治疗中的作用。
J Clin Oncol. 2014 Sep 10;32(26):2913-9. doi: 10.1200/JCO.2014.55.1143. Epub 2014 Aug 11.
4
Abiraterone acetate plus prednisone versus prednisone alone in chemotherapy-naive men with metastatic castration-resistant prostate cancer: patient-reported outcome results of a randomised phase 3 trial.醋酸阿比特龙联合泼尼松对比单独泼尼松用于化疗初治转移性去势抵抗性前列腺癌男性患者：一项随机 3 期临床试验的患者报告结局结果。
Lancet Oncol. 2013 Nov;14(12):1193-9. doi: 10.1016/S1470-2045(13)70424-8. Epub 2013 Sep 25.
5
Optimal timing of bisphosphonate administration in combination with samarium-153 oxabifore in the treatment of painful metastatic bone disease.双膦酸盐与钐-153 氧代双膦酸盐联合给药治疗疼痛性转移性骨病的最佳时机。
World J Nucl Med. 2013 Jan;12(1):14-8. doi: 10.4103/1450-1147.113939.
6
Strontium-89 (Sr-89) chloride in the treatment of various cancer patients with multiple bone metastases.氯化锶-89（Sr-89）治疗各类多发骨转移癌患者。
Int J Clin Oncol. 2014 Aug;19(4):739-43. doi: 10.1007/s10147-013-0597-7. Epub 2013 Jul 24.
7
Alpha emitter radium-223 and survival in metastatic prostate cancer.α 粒子发射体镭-223 与转移性前列腺癌的生存。
N Engl J Med. 2013 Jul 18;369(3):213-23. doi: 10.1056/NEJMoa1213755.
8
Targeted "bone-seeking" radiopharmaceuticals for palliative treatment of bone metastases: a systematic review and meta-analysis.用于骨转移姑息治疗的靶向“亲骨性”放射性药物：系统评价与荟萃分析
Q J Nucl Med Mol Imaging. 2012 Dec;56(6):538-43.
9
EORTC QLQ-BM22 and QLQ-C30 quality of life scores in patients with painful bone metastases of prostate cancer treated with strontium-89 radionuclide therapy.EORTC QLQ-BM22 和 QLQ-C30 生活质量评分在接受锶-89 放射性核素治疗的前列腺癌骨转移疼痛患者中的应用。
Ann Nucl Med. 2012 Jul;26(6):485-91. doi: 10.1007/s12149-012-0598-z. Epub 2012 Apr 3.
10
A randomized, dose-response, multicenter phase II study of radium-223 chloride for the palliation of painful bone metastases in patients with castration-resistant prostate cancer.镭-223 氯化物治疗去势抵抗性前列腺癌骨转移疼痛的随机、剂量反应、多中心 II 期研究。
Eur J Cancer. 2012 Mar;48(5):678-86. doi: 10.1016/j.ejca.2011.12.023. Epub 2012 Feb 15.
Zotero 插件