a Department of Psychology, Faculty of Social Sciences , University of Haifa , Haifa , Israel.
b McLean Hospital, Harvard Medical School , Belmont , MA , USA.
Psychother Res. 2018 Nov;28(6):958-968. doi: 10.1080/10503307.2017.1292066. Epub 2017 Feb 22.
The present study examined the relationship between positive affect (PA) and negative affect (NA) along the course of combined cognitive behavior therapy and pharmacological treatment for major depressive disorder (MDD).
Participants were 165 individuals who sought treatment for MDD in a partial hospital setting. Participants' PA, NA, and depressive symptoms were measured at pre- and post-treatment and PA and NA were measured at up to 10 additional measurements along the course of treatment.
Results indicated that PA at pre-treatment predicted depressive symptoms at post-treatment above and beyond NA and the PA*NA interaction. However, an analysis of patterns of change during treatment using lower level mediational modeling in a multilevel framework indicated that NA predicted subsequent PA to a greater extent than vice versa.
Though many treatments for MDD predominantly focus on reducing NA, our findings suggest that PA may be an important predictor of outcome in treatment for MDD, and that the inclusion of interventions to increase the experience of PA may help improve the efficacy of treatment.
本研究考察了在针对重度抑郁症（MDD）的联合认知行为疗法和药物治疗过程中，积极情绪（PA）和消极情绪（NA）之间的关系。
参与者为 165 名在部分住院环境中寻求 MDD 治疗的个体。在治疗前和治疗后测量参与者的 PA、NA 和抑郁症状，并在治疗过程中最多测量 10 个额外的时间点测量 PA 和 NA。
结果表明，治疗前的 PA 预测了治疗后的抑郁症状，超过了 NA 和 PA*NA 交互作用。然而，使用多层次框架中的较低层次中介模型对治疗过程中的变化模式进行分析表明，NA 对随后的 PA 的预测作用大于反之。
尽管许多 MDD 的治疗方法主要侧重于减少 NA，但我们的研究结果表明，PA 可能是 MDD 治疗结果的一个重要预测因素，并且包含增加 PA 体验的干预措施可能有助于提高治疗的效果。
