Li Mingzhao, Wang Hui, Li Wei, Shi Juanzi
a The ART Center, Northwest Women's and Children's Hospital , Xi'an , China.
Gynecol Endocrinol. 2017 Jun;33(6):458-461. doi: 10.1080/09513590.2017.1291609. Epub 2017 Mar 3.
To investigate whether the normal sperm morphology rate (NSMR) can affect the clinical outcomes of rescue-ICSI(R-ICSI) patients.
Based on different NSMR, the patients were divided into two groups as follows: NSMR < 4% and NSMR ≥ 4% group. Main outcomes compared were fertilization, cleavage, normal fertilization, high-quality embryo, transferrable embryo, no transferrable embryo cycles, implantation, clinical pregnancy and abortion rate. Some men's and women's basic parameters were compared between pregnancy and non-pregnancy group.
The basic parameter such as female age, endometrial thickness, infertility duration, Gn administration, Gn days, basal serum FSH and basal serum E2 found no significant difference between NSMR < 4% and NSMR ≥ 4% group (p > 0.05). There was no significant difference in aspects of the number of retrieved oocytes, the number of transferred embryos, fertilization, cleavage, normal fertilization, high-quality embryo, transferrable embryo, no transferred embryo cycle, implantation, clinical pregnancy and abortion rate between two groups (p > 0.05). Between pregnancy and non-pregnancy group, we observed no significant difference in the female age, the number of retrieved oocytes, the number of high-quality embryo, the number of transferrable embryos, Gn administration, Gn does, endometrial thickness, infertility duration, basal serum FSH, basal serum E2, sperm concentration and progressively motile sperm (p > 0.05).
Teratospermia made no effect on clinical outcomes of rescue-ICSI(R-ICSI) patients.
探讨正常精子形态率(NSMR)是否会影响补救性卵胞浆内单精子注射(R-ICSI)患者的临床结局。
根据不同的NSMR,将患者分为以下两组:NSMR<4%组和NSMR≥4%组。比较的主要结局包括受精、卵裂、正常受精、优质胚胎、可移植胚胎、不可移植胚胎周期、着床、临床妊娠和流产率。比较妊娠组和非妊娠组的一些男女基本参数。
NSMR<4%组和NSMR≥4%组之间,女性年龄、子宫内膜厚度、不孕持续时间、促性腺激素(Gn)使用情况、Gn使用天数、基础血清促卵泡生成素(FSH)和基础血清雌二醇(E2)等基本参数无显著差异(p>0.05)。两组在获卵数、移植胚胎数、受精、卵裂、正常受精、优质胚胎、可移植胚胎、未移植胚胎周期、着床、临床妊娠和流产率方面无显著差异(p>0.05)。在妊娠组和非妊娠组之间,我们观察到女性年龄、获卵数、优质胚胎数、可移植胚胎数、Gn使用情况、Gn剂量、子宫内膜厚度、不孕持续时间、基础血清FSH、基础血清E2、精子浓度和进行性运动精子方面无显著差异(p>0.05)。
畸形精子症对补救性ICSI(R-ICSI)患者的临床结局无影响。