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正常精子形态率(NSMR)对补救性卵胞浆内单精子注射(R-ICSI)患者临床结局的影响。

Effect of normal sperm morphology rate (NSMR) on clinical outcomes for rescue-ICSI(R-ICSI) patients.

作者信息

Li Mingzhao, Wang Hui, Li Wei, Shi Juanzi

机构信息

a The ART Center, Northwest Women's and Children's Hospital , Xi'an , China.

出版信息

Gynecol Endocrinol. 2017 Jun;33(6):458-461. doi: 10.1080/09513590.2017.1291609. Epub 2017 Mar 3.

Abstract

PURPOSE

To investigate whether the normal sperm morphology rate (NSMR) can affect the clinical outcomes of rescue-ICSI(R-ICSI) patients.

METHODS

Based on different NSMR, the patients were divided into two groups as follows: NSMR < 4% and NSMR ≥ 4% group. Main outcomes compared were fertilization, cleavage, normal fertilization, high-quality embryo, transferrable embryo, no transferrable embryo cycles, implantation, clinical pregnancy and abortion rate. Some men's and women's basic parameters were compared between pregnancy and non-pregnancy group.

RESULTS

The basic parameter such as female age, endometrial thickness, infertility duration, Gn administration, Gn days, basal serum FSH and basal serum E2 found no significant difference between NSMR < 4% and NSMR ≥ 4% group (p > 0.05). There was no significant difference in aspects of the number of retrieved oocytes, the number of transferred embryos, fertilization, cleavage, normal fertilization, high-quality embryo, transferrable embryo, no transferred embryo cycle, implantation, clinical pregnancy and abortion rate between two groups (p > 0.05). Between pregnancy and non-pregnancy group, we observed no significant difference in the female age, the number of retrieved oocytes, the number of high-quality embryo, the number of transferrable embryos, Gn administration, Gn does, endometrial thickness, infertility duration, basal serum FSH, basal serum E2, sperm concentration and progressively motile sperm (p > 0.05).

CONCLUSIONS

Teratospermia made no effect on clinical outcomes of rescue-ICSI(R-ICSI) patients.

摘要

目的

探讨正常精子形态率(NSMR)是否会影响补救性卵胞浆内单精子注射(R-ICSI)患者的临床结局。

方法

根据不同的NSMR,将患者分为以下两组:NSMR<4%组和NSMR≥4%组。比较的主要结局包括受精、卵裂、正常受精、优质胚胎、可移植胚胎、不可移植胚胎周期、着床、临床妊娠和流产率。比较妊娠组和非妊娠组的一些男女基本参数。

结果

NSMR<4%组和NSMR≥4%组之间,女性年龄、子宫内膜厚度、不孕持续时间、促性腺激素(Gn)使用情况、Gn使用天数、基础血清促卵泡生成素(FSH)和基础血清雌二醇(E2)等基本参数无显著差异(p>0.05)。两组在获卵数、移植胚胎数、受精、卵裂、正常受精、优质胚胎、可移植胚胎、未移植胚胎周期、着床、临床妊娠和流产率方面无显著差异(p>0.05)。在妊娠组和非妊娠组之间,我们观察到女性年龄、获卵数、优质胚胎数、可移植胚胎数、Gn使用情况、Gn剂量、子宫内膜厚度、不孕持续时间、基础血清FSH、基础血清E2、精子浓度和进行性运动精子方面无显著差异(p>0.05)。

结论

畸形精子症对补救性ICSI(R-ICSI)患者的临床结局无影响。

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