Narusaka Mari, Narusaka Yoshihiro
a Research Institute for Biological Sciences Okayama , Okayama , Japan.
Plant Signal Behav. 2017 Mar 4;12(3):e1293222. doi: 10.1080/15592324.2017.1293222.
Plant activators activate systemic acquired resistance-like defense responses or induced systemic resistance, and thus protect plants from pathogens. We screened a chemical library composed of structurally diverse small molecules. We isolated six plant immune-inducing thienopyrimidine-type compounds and their analogous compounds. It was observed that the core structure of thienopyrimidine plays a role in induced resistance in plants. Furthermore, we highlight the protective effect of thienopyrimidine-type compounds against both hemibiotrophic fungal pathogen, Colletotrichum higginsianum, and bacterial pathogen, Pseudomonas syringae pv. maculicola, in Arabidopsis thaliana. We suggest that thienopyrimidine-type compounds could be potential lead compounds as novel plant activators, and can be useful and effective agrochemicals against various plant diseases.
植物激活剂可激活系统性获得抗性样防御反应或诱导系统性抗性，从而保护植物免受病原体侵害。我们筛选了一个由结构多样的小分子组成的化学文库。我们分离出了六种诱导植物免疫的噻吩并嘧啶类化合物及其类似化合物。据观察，噻吩并嘧啶的核心结构在植物诱导抗性中发挥作用。此外，我们强调了噻吩并嘧啶类化合物对拟南芥中半活体营养型真菌病原体烟草炭疽菌和细菌病原体丁香假单胞菌番茄致病变种的保护作用。我们认为，噻吩并嘧啶类化合物可能是作为新型植物激活剂的潜在先导化合物，并且可以成为防治各种植物病害的有用且有效的农用化学品。
