Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study.
作者信息
Lim Hui, Powell Sioned, Mcnamara Helen C, Howie A Forbes, Doust Ann, Bowman Maria E, Smith Roger, Norman Jane E, Stock Sarah J
机构信息
Tommy's Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh Queen's Medical Research Institute, Edinburgh, United Kingdom.
Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, Newcastle, New South Wales, Australia.
出版信息
PLoS One. 2017 Mar 9;12(3):e0173732. doi: 10.1371/journal.pone.0173732. eCollection 2017.
OBJECTIVE
The objective of the study was to analyse placental hormone profiles in twin pregnancies to determine if they could be used to predict preterm birth.
STUDY DESIGN
Progesterone, estradiol, estriol and corticotropin-releasing hormone were measured using competitive immunoassay and radioimmunoassay in serum and saliva samples of 98 women with twin pregnancies,at 3 or more gestational timepoints. Hormone profiles throughout gestation were compared between very preterm (<34 weeks; n = 8), preterm (<37 weeks; n = 40) and term (37+ weeks; n = 50) deliveries.
RESULTS
No significant differences were found between preterm and term deliveries in either absolute hormone concentrations or ratios. Estimated hormone concentrations and ratios at 26 weeks did not appear to predict preterm delivery. Salivary and serum hormone concentrations were generally poorly correlated.
CONCLUSION
Our results suggest that serial progesterone, estradiol, estriol and corticotropin-releasing hormone measurements in saliva and serum are not robust biomarkers for preterm birth in twin pregnancies.
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