Ko Dong Ryul, Jang Ji Eun, Chung Sung Phil, Lee Jong Wook, Lee Hye Sun, Hong Jung Hwa, Kong Taeyoung, You Je Sung, Park Incheol
a Department of Emergency Medicine , Yonsei University College of Medicine , Seoul , Republic of Korea.
b Division of Hematology, Department of Internal Medicine , Yonsei University College of Medicine , Seoul , Republic of Korea.
Leuk Lymphoma. 2017 Oct;58(10):2387-2394. doi: 10.1080/10428194.2017.1296142. Epub 2017 Mar 2.
The delta neutrophil index (DNI) reflects the fraction of circulating immature granulocytes. We evaluated the usefulness of DNI values in patients with acute myeloid leukemia (AML) to distinguish the acute stage of acute promyelocytic leukemia (APL). We analyzed patients retrospectively who were first diagnosed with AML upon admission to the emergency department (ED). Thirty of the 134 patients (22.4%) were diagnosed with APL on ED admission. The univariate analysis and multivariate logistic regression models revealed that DNI values differed significantly between APL and non-APL AML patients on days 0, 1 and 2. Increased predictability for APL was associated with a DNI greater than 24.2% on ED admission, greater than 23.6% on day 1 and greater than 44% on day 2 in patients with AML. DNI values of patients with AML could discriminate the acute stage of APL from AML for immediate initiation of all-trans retinoic acid therapy.
δ中性粒细胞指数（DNI）反映循环中未成熟粒细胞的比例。我们评估了DNI值在急性髓系白血病（AML）患者中区分急性早幼粒细胞白血病（APL）急性期的效用。我们对急诊科（ED）入院时首次诊断为AML的患者进行了回顾性分析。134例患者中有30例（22.4%）在ED入院时被诊断为APL。单因素分析和多因素逻辑回归模型显示，APL患者与非APL AML患者在第0、1和2天的DNI值有显著差异。AML患者中，ED入院时DNI大于24.2%、第1天大于23.6%、第2天大于44%与APL预测性增加相关。AML患者的DNI值可将APL急性期与AML区分开来，以便立即开始全反式维甲酸治疗。
