正常人水浸过程中循环中的阿片肽
Circulating opioid peptides during water immersion in normal man.
作者信息
Coruzzi P, Ravanetti C, Musiari L, Biggi A, Vescovi P P, Novarini A
机构信息
Istituto di Semeiotica Medica, University of Parma, Italy.
出版信息
Clin Sci (Lond). 1988 Feb;74(2):133-6. doi: 10.1042/cs0740133.
PMID:2827940
Abstract
- This study was designed to evaluate variations in plasma beta-endorphin, methionine-enkephalin, adrenocorticotropic hormone and serum prolactin in healthy volunteers during head-out water immersion. 2. Water immersion induced an increase in methionine-enkephalin plasma levels, which was associated with a significant fall in mean arterial pressure and heart rate. 3. Conversely, a suppression of plasma beta-endorphin, adrenocorticotropic hormone and serum prolactin was detected during water immersion. 4. We suggest that a dopaminergic inhibitory control mechanism may be involved in regulating circulating levels of beta-endorphin, adrenocorticotropic hormone and prolactin in normal subjects undergoing extracellular fluid volume expansion produced by water immersion.
摘要
- 本研究旨在评估健康志愿者在头部露出水面的水浸过程中血浆β-内啡肽、甲硫氨酸脑啡肽、促肾上腺皮质激素和血清催乳素的变化。2. 水浸导致甲硫氨酸脑啡肽血浆水平升高，这与平均动脉压和心率显著下降有关。3. 相反，在水浸过程中检测到血浆β-内啡肽、促肾上腺皮质激素和血清催乳素受到抑制。4. 我们认为，多巴胺能抑制控制机制可能参与调节正常受试者在水浸引起的细胞外液量扩张过程中β-内啡肽、促肾上腺皮质激素和催乳素的循环水平。
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