一例促甲状腺激素/生长激素分泌型垂体瘤与甲状腺乳头状癌并存的病例：发病机制及管理面临的挑战

A case of coexistence of TSH/GH-secreting pituitary tumor and papillary thyroid carcinoma: Challenges in pathogenesis and management.

作者信息

Kiatpanabhikul Phatharaporn, Shuangshoti Shanop, Chantra Kraisri, Navicharern Patpong, Kingpetch Kanaungnit, Houngngam Natnicha, Snabboon Thiti

机构信息

Department of Medicine, Charoenkrung pracharak Hospital, Medical Service Department, Bangkok Metropolitan Administration, Bangkok, Thailand.

Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

出版信息

J Clin Neurosci. 2017 Jul;41:78-80. doi: 10.1016/j.jocn.2017.02.050. Epub 2017 Mar 6.

DOI:10.1016/j.jocn.2017.02.050

PMID:28279554

Abstract

Co-existence of thyrotropin/growth hormone-secreting pituitary adenoma with differentiated thyroid carcinoma is exceedingly rare, with less than 15 cases having been reported. Its clinical presentation and treatment strategy are challenging. We report a case of pituitary macroadenoma, with clinical syndromes of acromegaly and hyperthyroidism, and a thyroid nodule, with cytologically confirmed to be a papillary thyroid carcinoma. Clinical implications, focusing on the strategy for proper management, and possible pathogenesis were discussed.

摘要

促甲状腺激素/生长激素分泌型垂体腺瘤与分化型甲状腺癌并存极为罕见，报告的病例不足15例。其临床表现和治疗策略具有挑战性。我们报告一例垂体大腺瘤，伴有肢端肥大症和甲状腺功能亢进的临床综合征，以及一个甲状腺结节，经细胞学检查确诊为乳头状甲状腺癌。本文讨论了其临床意义，重点是合理管理策略以及可能的发病机制。