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Overexpression of GPX4 in diabetic rat kidney alleviates renal injury induced by ferroptosis.糖尿病大鼠肾脏中GPX4的过表达减轻了铁死亡诱导的肾损伤。
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2型糖尿病肾病的诊断与管理

Diagnosis and Management of Type 2 Diabetic Kidney Disease.

作者信息

Doshi Simit M, Friedman Allon N

机构信息

Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

出版信息

Clin J Am Soc Nephrol. 2017 Aug 7;12(8):1366-1373. doi: 10.2215/CJN.11111016. Epub 2017 Mar 9.

DOI:10.2215/CJN.11111016
PMID:28280116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5544517/
Abstract

Type 2 diabetic kidney disease (DKD) is the most common cause of CKD and ESRD worldwide, and carries with it enormous human and societal costs. The goal of this review is to provide an update on the diagnosis and management of DKD based on a comprehensive review of the medical literature. Topics addressed include the evolving presentation of DKD, clinical differentiation of DKD from non-DKD, a state-of-the-art evaluation of current treatment strategies, and promising emerging treatments. It is expected that the review will help clinicians to diagnose and manage patients with DKD.

摘要

2型糖尿病肾病(DKD)是全球范围内慢性肾脏病(CKD)和终末期肾病(ESRD)的最常见病因,给人类和社会带来了巨大的成本。本综述的目的是在全面回顾医学文献的基础上,提供DKD诊断和管理的最新信息。涉及的主题包括DKD不断演变的表现、DKD与非DKD的临床鉴别、当前治疗策略的最新评估以及有前景的新兴治疗方法。预计该综述将有助于临床医生诊断和管理DKD患者。